A Transcriptionally Distinct CXCL13þCD103þCD8þ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Hagma H. Workel, Joyce M. Lubbers, Roland Arnold, Thalina M. Prins, Pieter van der Vlies, Kim de Lange, Tjalling Bosse, Inge C. van Gool, Florine A. Eggink, Maartje C. A. Wouters, Fenne L. Komdeur, Elisabeth C. van der Slikke, Carien L. Creutzberg, Arjan Kol, Annechien Plat, Mark Glaire, David N. Church, Hans W. Nijman, Marco de Bruyn

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The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation of tertiary lymphoid structures (TLSs). TLSs are thought to support antitumor immunity and are associated with improved prognosis. However, it remains unknown whether TLSs are formed in response to the general inflammatory character of the tumor microenvironment, or rather, are induced by (neo)antigen-specific adaptive immunity. We here report on the finding that the TGFb-dependent CD103þCD8þ tumor-infiltrating T-cell (TIL) subpopulation expressed and produced CXCL13. Accordingly,
Original languageEnglish
Pages (from-to)784-796
JournalCancer Immunology Research
Issue number5
Publication statusPublished - 1 May 2019
Externally publishedYes

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