Abdominal organ motion during inhalation and exhalation breath-holds: pancreatic motion at different lung volumes compared

Eelco Lens, Oliver J. Gurney-Champion, Daniël R. Tekelenburg, Zdenko van Kesteren, Michael J. Parkes, Geertjan van Tienhoven, Aart J. Nederveen, Astrid van der Horst, Arjan Bel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose Contrary to what is commonly assumed, organs continue to move during breath-holding. We investigated the influence of lung volume on motion magnitude during breath-holding and changes in velocity over the duration of breath-holding. Materials and methods Sixteen healthy subjects performed 60-second inhalation breath-holds in room-air, with lung volumes of ∼100% and ∼70% of the inspiratory capacity, and exhalation breath-holds, with lung volumes of ∼30% and ∼0% of the inspiratory capacity. During breath-holding, we obtained dynamic single-slice magnetic-resonance images with a time-resolution of 0.6 s. We used 2-dimensional image correlation to obtain the diaphragmatic and pancreatic velocity and displacement during breath-holding. Results Organ velocity was largest in the inferior–superior direction and was greatest during the first 10 s of breath-holding, with diaphragm velocities of 0.41 mm/s, 0.29 mm/s, 0.16 mm/s and 0.15 mm/s during BH100%, BH70%, BH30% and BH0%, respectively. Organ motion magnitudes were larger during inhalation breath-holds (diaphragm moved 9.8 and 9.0 mm during BH100% and BH70%, respectively) than during exhalation breath-holds (5.6 and 4.3 mm during BH30% and BH0%, respectively). Conclusion Using exhalation breath-holds rather than inhalation breath-holds and delaying irradiation until after the first 10 s of breath-holding may be advantageous for irradiation of abdominal tumors.
Original languageEnglish
Pages (from-to)268-275
JournalRadiotherapy and Oncology
Volume121
Issue number2
DOIs
Publication statusPublished - 2016
Externally publishedYes

Cite this

Lens, E., Gurney-Champion, O. J., Tekelenburg, D. R., van Kesteren, Z., Parkes, M. J., van Tienhoven, G., Nederveen, A. J., van der Horst, A., & Bel, A. (2016). Abdominal organ motion during inhalation and exhalation breath-holds: pancreatic motion at different lung volumes compared. Radiotherapy and Oncology, 121(2), 268-275. https://doi.org/10.1016/j.radonc.2016.09.012