Abstract
Introduction Abnormal glutamatergic transmission in cortico-striato-thalamo-cortical (CSTC) circuits is thought to be involved in the pathophysiology of Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Using proton magnetic resonance spectroscopy, the current study aimed to investigate regional concentrations of glutamatergic compounds in TD and OCD patients in comparison to healthy control subjects (HC). Material and methods Twenty-three TD patients, 20 OCD patients and 22 HC were included. Short echo-time single-voxel 3T MRS was obtained from dorsal anterior cingulate cortex (dACC) and midline bilateral thalamus. Results The 3-group comparison showed a significant difference in choline concentration in the thalamus. Thalamic choline was highest in OCD patients, showing a significant difference with TD, and a trend compared to HC (post-hoc analyses). Glutamine in dACC correlated negatively with tic severity scores in TD patients, while glutamate in thalamus correlated positively with anxiety severity scores in OCD patients. Conclusions These findings suggest subtle differences in metabolites in CSTC areas between TD and OCD. Alterations of choline concentrations seem to be both regional (only in thalamus, not in dACC) and disease specific in OCD pathology. The findings need replication in larger groups, but encourage further research into glutamatergic metabolites in TD and OCD.
| Original language | English |
|---|---|
| Pages (from-to) | 211-217 |
| Number of pages | 7 |
| Journal | Psychoneuroendocrinology |
| Volume | 77 |
| DOIs | |
| Publication status | Published - 1 Mar 2017 |
Cite this
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Abnormalities in metabolite concentrations in tourette's disorder and obsessive-compulsive disorder—A proton magnetic resonance spectroscopy study. / Fan, Siyan; Cath, Danielle C.; van den Heuvel, Odile A.; van der Werf, Ysbrand D.; Schöls, Caroline; Veltman, Dick J.; Pouwels, Petra J.W.
In: Psychoneuroendocrinology, Vol. 77, 01.03.2017, p. 211-217.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Abnormalities in metabolite concentrations in tourette's disorder and obsessive-compulsive disorder—A proton magnetic resonance spectroscopy study
AU - Fan, Siyan
AU - Cath, Danielle C.
AU - van den Heuvel, Odile A.
AU - van der Werf, Ysbrand D.
AU - Schöls, Caroline
AU - Veltman, Dick J.
AU - Pouwels, Petra J.W.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Introduction Abnormal glutamatergic transmission in cortico-striato-thalamo-cortical (CSTC) circuits is thought to be involved in the pathophysiology of Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Using proton magnetic resonance spectroscopy, the current study aimed to investigate regional concentrations of glutamatergic compounds in TD and OCD patients in comparison to healthy control subjects (HC). Material and methods Twenty-three TD patients, 20 OCD patients and 22 HC were included. Short echo-time single-voxel 3T MRS was obtained from dorsal anterior cingulate cortex (dACC) and midline bilateral thalamus. Results The 3-group comparison showed a significant difference in choline concentration in the thalamus. Thalamic choline was highest in OCD patients, showing a significant difference with TD, and a trend compared to HC (post-hoc analyses). Glutamine in dACC correlated negatively with tic severity scores in TD patients, while glutamate in thalamus correlated positively with anxiety severity scores in OCD patients. Conclusions These findings suggest subtle differences in metabolites in CSTC areas between TD and OCD. Alterations of choline concentrations seem to be both regional (only in thalamus, not in dACC) and disease specific in OCD pathology. The findings need replication in larger groups, but encourage further research into glutamatergic metabolites in TD and OCD.
AB - Introduction Abnormal glutamatergic transmission in cortico-striato-thalamo-cortical (CSTC) circuits is thought to be involved in the pathophysiology of Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Using proton magnetic resonance spectroscopy, the current study aimed to investigate regional concentrations of glutamatergic compounds in TD and OCD patients in comparison to healthy control subjects (HC). Material and methods Twenty-three TD patients, 20 OCD patients and 22 HC were included. Short echo-time single-voxel 3T MRS was obtained from dorsal anterior cingulate cortex (dACC) and midline bilateral thalamus. Results The 3-group comparison showed a significant difference in choline concentration in the thalamus. Thalamic choline was highest in OCD patients, showing a significant difference with TD, and a trend compared to HC (post-hoc analyses). Glutamine in dACC correlated negatively with tic severity scores in TD patients, while glutamate in thalamus correlated positively with anxiety severity scores in OCD patients. Conclusions These findings suggest subtle differences in metabolites in CSTC areas between TD and OCD. Alterations of choline concentrations seem to be both regional (only in thalamus, not in dACC) and disease specific in OCD pathology. The findings need replication in larger groups, but encourage further research into glutamatergic metabolites in TD and OCD.
KW - Choline
KW - Dorsal cingulate cortex
KW - Magnetic resonance spectroscopy
KW - Obsessive-compulsive disorder
KW - Thalamus
KW - Tourette's disorder
UR - http://www.scopus.com/inward/record.url?scp=85009423438&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2016.12.007
DO - 10.1016/j.psyneuen.2016.12.007
M3 - Article
VL - 77
SP - 211
EP - 217
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -