Acquisition of Drug-Resistant Bacteria: Role of Gastric Acid Suppression

Roelof Paulus Johannes Willems

Research output: PhD ThesisPhd-Thesis - Research and graduation internal


Over the past decades, antibiotic-resistant bacteria have become increasingly prevalent, posing a significant threat to public health. Although classic risk factors are well-established, the potential risk associated with proton pump inhibitors has received little attention, despite the long-standing theory that the acidity of the stomach is a first line of defense of the host against enteric bacterial disease. In part I of this thesis we investigate the role of gastric acid suppression as a risk factor for the acquisition of multidrug-resistant micro-organisms, with a focus on (extended spectrum beta-lactamases) ESBL-producing Enterobacterales. In addition, in part II of this thesis, we (1) aimed to determine the risk of infection in patients colonized with multidrug-resistant bacteria and (2) studied the composition of the microbiota and associated metabolome in carriers and non-carriers of ESBL-producing E. coli.
Original languageEnglish
QualificationDoctor of Philosophy
  • Vandenbroucke-Grauls, C.M.J.E., Supervisor, External person
  • van Dijk, Karin, Co-supervisor, External person
  • de Greeff, S.C., Co-supervisor, External person
Award date8 May 2023
Print ISBNs9789464197501
Publication statusPublished - 8 May 2023

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