Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Zhen Ping, Si Chen, Sjoerd J. F. Hermans, Keane J. G. Kenswil, Jacqueline Feyen, Claire van Dijk, Eric M. J. Bindels, Athina M. Mylona, Niken M. Adisty, Remco M. Hoogenboezem, Mathijs A. Sanders, Eline M. P. Cremers, Dicky J. Lindenbergh-Kortleve, Janneke N. Samsom, Arjan A. van de Loosdrecht, Marc H. G. P. Raaijmakers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.
Original languageEnglish
Pages (from-to)536-541
Number of pages6
JournalLeukemia
Volume33
Issue number2
Early online date2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

Ping, Z., Chen, S., Hermans, S. J. F., Kenswil, K. J. G., Feyen, J., van Dijk, C., ... Raaijmakers, M. H. G. P. (2019). Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. Leukemia, 33(2), 536-541. https://doi.org/10.1038/s41375-018-0267-x