Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Zhen Ping, Si Chen, Sjoerd J. F. Hermans, Keane J. G. Kenswil, Jacqueline Feyen, Claire van Dijk, Eric M. J. Bindels, Athina M. Mylona, Niken M. Adisty, Remco M. Hoogenboezem, Mathijs A. Sanders, Eline M. P. Cremers, Dicky J. Lindenbergh-Kortleve, Janneke N. Samsom, Arjan A. van de Loosdrecht, Marc H. G. P. Raaijmakers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.
LanguageEnglish
Pages536-541
Number of pages6
JournalLeukemia
Volume33
Issue number2
Early online date2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

Ping, Z., Chen, S., Hermans, S. J. F., Kenswil, K. J. G., Feyen, J., van Dijk, C., ... Raaijmakers, M. H. G. P. (2019). Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. Leukemia, 33(2), 536-541. https://doi.org/10.1038/s41375-018-0267-x
Ping, Zhen ; Chen, Si ; Hermans, Sjoerd J. F. ; Kenswil, Keane J. G. ; Feyen, Jacqueline ; van Dijk, Claire ; Bindels, Eric M. J. ; Mylona, Athina M. ; Adisty, Niken M. ; Hoogenboezem, Remco M. ; Sanders, Mathijs A. ; Cremers, Eline M. P. ; Lindenbergh-Kortleve, Dicky J. ; Samsom, Janneke N. ; van de Loosdrecht, Arjan A. ; Raaijmakers, Marc H. G. P. / Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. In: Leukemia. 2019 ; Vol. 33, No. 2. pp. 536-541.
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title = "Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes",
abstract = "Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.",
author = "Zhen Ping and Si Chen and Hermans, {Sjoerd J. F.} and Kenswil, {Keane J. G.} and Jacqueline Feyen and {van Dijk}, Claire and Bindels, {Eric M. J.} and Mylona, {Athina M.} and Adisty, {Niken M.} and Hoogenboezem, {Remco M.} and Sanders, {Mathijs A.} and Cremers, {Eline M. P.} and Lindenbergh-Kortleve, {Dicky J.} and Samsom, {Janneke N.} and {van de Loosdrecht}, {Arjan A.} and Raaijmakers, {Marc H. G. P.}",
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Ping, Z, Chen, S, Hermans, SJF, Kenswil, KJG, Feyen, J, van Dijk, C, Bindels, EMJ, Mylona, AM, Adisty, NM, Hoogenboezem, RM, Sanders, MA, Cremers, EMP, Lindenbergh-Kortleve, DJ, Samsom, JN, van de Loosdrecht, AA & Raaijmakers, MHGP 2019, 'Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes', Leukemia, vol. 33, no. 2, pp. 536-541. https://doi.org/10.1038/s41375-018-0267-x

Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. / Ping, Zhen; Chen, Si; Hermans, Sjoerd J. F.; Kenswil, Keane J. G.; Feyen, Jacqueline; van Dijk, Claire; Bindels, Eric M. J.; Mylona, Athina M.; Adisty, Niken M.; Hoogenboezem, Remco M.; Sanders, Mathijs A.; Cremers, Eline M. P.; Lindenbergh-Kortleve, Dicky J.; Samsom, Janneke N.; van de Loosdrecht, Arjan A.; Raaijmakers, Marc H. G. P.

In: Leukemia, Vol. 33, No. 2, 01.02.2019, p. 536-541.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

AU - Ping, Zhen

AU - Chen, Si

AU - Hermans, Sjoerd J. F.

AU - Kenswil, Keane J. G.

AU - Feyen, Jacqueline

AU - van Dijk, Claire

AU - Bindels, Eric M. J.

AU - Mylona, Athina M.

AU - Adisty, Niken M.

AU - Hoogenboezem, Remco M.

AU - Sanders, Mathijs A.

AU - Cremers, Eline M. P.

AU - Lindenbergh-Kortleve, Dicky J.

AU - Samsom, Janneke N.

AU - van de Loosdrecht, Arjan A.

AU - Raaijmakers, Marc H. G. P.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

AB - Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

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DO - 10.1038/s41375-018-0267-x

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