Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863

A. Zurlo, L. Collette, G. van Tienhoven, L. E. Blank, P. Warde, J. B. Dubois, W. Jeanneret, G. Storme, J. Bernier, A. Kuten, M. Pierart, M. Bolla

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: We analysed the acute toxicity observed in the European Organisation for Research and Treatment of Cancer (EORTC) randomised trial 22863 comparing conventional external irradiation with or without an agonist analogue of gonadotropin-releasing hormone in high-risk prostate cancer patients. Methods: Four hundred five patients that received a dose of at least 30 Gy were considered evaluable for acute toxicity assessment. Toxicity was grouped in a few categories: general, genito-urinary, and lower gastro-intestinal. Univariate and multivariate analyses were performed using the World Health Organisation (WHO) toxicity score and grouping together toxicity scores in different bimodal and trimodal groups. Results: Overall, our data show that age, previous surgery and irradiation dose are important predictive factors for acute toxicity, but not the use of combined hormone therapy. Fifteen percent of patients suffered of moderate to severe acute toxicity (WHO G3-G4). Life threatening toxicity was observed in six cases (1.5%). Conclusions: The assessment of toxicity combining in different groups the original five scores scale produced conflicting results similar to those commonly reported in literature. Interpretation of the role of pre-treatment factors with uneven distribution in the study requires careful evaluation. These data obtained with conventional curative irradiation of high-risk prostate cancer patients are proposed for comparison with results achieved using modern state-of-the-art irradiation techniques. © 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)125-132
JournalEuropean Urology
Volume42
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

Cite this

Zurlo, A. ; Collette, L. ; van Tienhoven, G. ; Blank, L. E. ; Warde, P. ; Dubois, J. B. ; Jeanneret, W. ; Storme, G. ; Bernier, J. ; Kuten, A. ; Pierart, M. ; Bolla, M. / Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863. In: European Urology. 2002 ; Vol. 42, No. 2. pp. 125-132.
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title = "Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863",
abstract = "Objectives: We analysed the acute toxicity observed in the European Organisation for Research and Treatment of Cancer (EORTC) randomised trial 22863 comparing conventional external irradiation with or without an agonist analogue of gonadotropin-releasing hormone in high-risk prostate cancer patients. Methods: Four hundred five patients that received a dose of at least 30 Gy were considered evaluable for acute toxicity assessment. Toxicity was grouped in a few categories: general, genito-urinary, and lower gastro-intestinal. Univariate and multivariate analyses were performed using the World Health Organisation (WHO) toxicity score and grouping together toxicity scores in different bimodal and trimodal groups. Results: Overall, our data show that age, previous surgery and irradiation dose are important predictive factors for acute toxicity, but not the use of combined hormone therapy. Fifteen percent of patients suffered of moderate to severe acute toxicity (WHO G3-G4). Life threatening toxicity was observed in six cases (1.5{\%}). Conclusions: The assessment of toxicity combining in different groups the original five scores scale produced conflicting results similar to those commonly reported in literature. Interpretation of the role of pre-treatment factors with uneven distribution in the study requires careful evaluation. These data obtained with conventional curative irradiation of high-risk prostate cancer patients are proposed for comparison with results achieved using modern state-of-the-art irradiation techniques. {\circledC} 2002 Elsevier Science B.V. All rights reserved.",
author = "A. Zurlo and L. Collette and {van Tienhoven}, G. and Blank, {L. E.} and P. Warde and Dubois, {J. B.} and W. Jeanneret and G. Storme and J. Bernier and A. Kuten and M. Pierart and M. Bolla",
year = "2002",
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journal = "European Urology",
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Zurlo, A, Collette, L, van Tienhoven, G, Blank, LE, Warde, P, Dubois, JB, Jeanneret, W, Storme, G, Bernier, J, Kuten, A, Pierart, M & Bolla, M 2002, 'Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863' European Urology, vol. 42, no. 2, pp. 125-132. https://doi.org/10.1016/S0302-2838(02)00257-9

Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863. / Zurlo, A.; Collette, L.; van Tienhoven, G.; Blank, L. E.; Warde, P.; Dubois, J. B.; Jeanneret, W.; Storme, G.; Bernier, J.; Kuten, A.; Pierart, M.; Bolla, M.

In: European Urology, Vol. 42, No. 2, 2002, p. 125-132.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863

AU - Zurlo, A.

AU - Collette, L.

AU - van Tienhoven, G.

AU - Blank, L. E.

AU - Warde, P.

AU - Dubois, J. B.

AU - Jeanneret, W.

AU - Storme, G.

AU - Bernier, J.

AU - Kuten, A.

AU - Pierart, M.

AU - Bolla, M.

PY - 2002

Y1 - 2002

N2 - Objectives: We analysed the acute toxicity observed in the European Organisation for Research and Treatment of Cancer (EORTC) randomised trial 22863 comparing conventional external irradiation with or without an agonist analogue of gonadotropin-releasing hormone in high-risk prostate cancer patients. Methods: Four hundred five patients that received a dose of at least 30 Gy were considered evaluable for acute toxicity assessment. Toxicity was grouped in a few categories: general, genito-urinary, and lower gastro-intestinal. Univariate and multivariate analyses were performed using the World Health Organisation (WHO) toxicity score and grouping together toxicity scores in different bimodal and trimodal groups. Results: Overall, our data show that age, previous surgery and irradiation dose are important predictive factors for acute toxicity, but not the use of combined hormone therapy. Fifteen percent of patients suffered of moderate to severe acute toxicity (WHO G3-G4). Life threatening toxicity was observed in six cases (1.5%). Conclusions: The assessment of toxicity combining in different groups the original five scores scale produced conflicting results similar to those commonly reported in literature. Interpretation of the role of pre-treatment factors with uneven distribution in the study requires careful evaluation. These data obtained with conventional curative irradiation of high-risk prostate cancer patients are proposed for comparison with results achieved using modern state-of-the-art irradiation techniques. © 2002 Elsevier Science B.V. All rights reserved.

AB - Objectives: We analysed the acute toxicity observed in the European Organisation for Research and Treatment of Cancer (EORTC) randomised trial 22863 comparing conventional external irradiation with or without an agonist analogue of gonadotropin-releasing hormone in high-risk prostate cancer patients. Methods: Four hundred five patients that received a dose of at least 30 Gy were considered evaluable for acute toxicity assessment. Toxicity was grouped in a few categories: general, genito-urinary, and lower gastro-intestinal. Univariate and multivariate analyses were performed using the World Health Organisation (WHO) toxicity score and grouping together toxicity scores in different bimodal and trimodal groups. Results: Overall, our data show that age, previous surgery and irradiation dose are important predictive factors for acute toxicity, but not the use of combined hormone therapy. Fifteen percent of patients suffered of moderate to severe acute toxicity (WHO G3-G4). Life threatening toxicity was observed in six cases (1.5%). Conclusions: The assessment of toxicity combining in different groups the original five scores scale produced conflicting results similar to those commonly reported in literature. Interpretation of the role of pre-treatment factors with uneven distribution in the study requires careful evaluation. These data obtained with conventional curative irradiation of high-risk prostate cancer patients are proposed for comparison with results achieved using modern state-of-the-art irradiation techniques. © 2002 Elsevier Science B.V. All rights reserved.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/12160582

U2 - 10.1016/S0302-2838(02)00257-9

DO - 10.1016/S0302-2838(02)00257-9

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SP - 125

EP - 132

JO - European Urology

JF - European Urology

SN - 0302-2838

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