Adhesion and signaling mediated by the cytoplasmic tails of leucocyte integrins

Y van Kooyk, M Lub, C G Figdor

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Integrins not only mediate cell adhesion but also contribute to a variety of other cellular processes including proliferation, cytokine production, cytotoxicity and apoptosis. They act as bi-directional signal transducers, mediating signaling from inside-to-outside the cell and from outside-to-inside the cell. Evidence is emerging that signaling through leukocyte integrins (beta 2 and beta 7) is distinct from signaling by the more widely distributed beta 1 integrins. Here we discuss the role of the cytoplasmic domains of leukocyte integrins and that of cytosolic proteins that bind integrins in mediating signal transduction. Distinct sites in the alpha as well as the common beta chain contribute to this process. We also show that beta 2 integrin distribution on the cell surface is of particular relevance for leukocytes to rapidly alter their adhesive state and display their highly dynamic adhesive behavior. From these and recently published findings the picture is arising that particular cell functions may be supported by integrin-specific signaling pathways.

Original languageEnglish
Pages (from-to)247-54
Number of pages8
JournalCell adhesion and communication
Volume6
Issue number2-3
Publication statusPublished - 1998

Cite this

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title = "Adhesion and signaling mediated by the cytoplasmic tails of leucocyte integrins",
abstract = "Integrins not only mediate cell adhesion but also contribute to a variety of other cellular processes including proliferation, cytokine production, cytotoxicity and apoptosis. They act as bi-directional signal transducers, mediating signaling from inside-to-outside the cell and from outside-to-inside the cell. Evidence is emerging that signaling through leukocyte integrins (beta 2 and beta 7) is distinct from signaling by the more widely distributed beta 1 integrins. Here we discuss the role of the cytoplasmic domains of leukocyte integrins and that of cytosolic proteins that bind integrins in mediating signal transduction. Distinct sites in the alpha as well as the common beta chain contribute to this process. We also show that beta 2 integrin distribution on the cell surface is of particular relevance for leukocytes to rapidly alter their adhesive state and display their highly dynamic adhesive behavior. From these and recently published findings the picture is arising that particular cell functions may be supported by integrin-specific signaling pathways.",
keywords = "Amino Acid Sequence, Animals, Cell Adhesion/immunology, Cytoplasm/chemistry, Humans, Integrins/genetics, Leukocytes/chemistry, Molecular Sequence Data, Signal Transduction/immunology",
author = "{van Kooyk}, Y and M Lub and Figdor, {C G}",
year = "1998",
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journal = "Cell adhesion and communication",
issn = "1023-7046",
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}

Adhesion and signaling mediated by the cytoplasmic tails of leucocyte integrins. / van Kooyk, Y; Lub, M; Figdor, C G.

In: Cell adhesion and communication, Vol. 6, No. 2-3, 1998, p. 247-54.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Adhesion and signaling mediated by the cytoplasmic tails of leucocyte integrins

AU - van Kooyk, Y

AU - Lub, M

AU - Figdor, C G

PY - 1998

Y1 - 1998

N2 - Integrins not only mediate cell adhesion but also contribute to a variety of other cellular processes including proliferation, cytokine production, cytotoxicity and apoptosis. They act as bi-directional signal transducers, mediating signaling from inside-to-outside the cell and from outside-to-inside the cell. Evidence is emerging that signaling through leukocyte integrins (beta 2 and beta 7) is distinct from signaling by the more widely distributed beta 1 integrins. Here we discuss the role of the cytoplasmic domains of leukocyte integrins and that of cytosolic proteins that bind integrins in mediating signal transduction. Distinct sites in the alpha as well as the common beta chain contribute to this process. We also show that beta 2 integrin distribution on the cell surface is of particular relevance for leukocytes to rapidly alter their adhesive state and display their highly dynamic adhesive behavior. From these and recently published findings the picture is arising that particular cell functions may be supported by integrin-specific signaling pathways.

AB - Integrins not only mediate cell adhesion but also contribute to a variety of other cellular processes including proliferation, cytokine production, cytotoxicity and apoptosis. They act as bi-directional signal transducers, mediating signaling from inside-to-outside the cell and from outside-to-inside the cell. Evidence is emerging that signaling through leukocyte integrins (beta 2 and beta 7) is distinct from signaling by the more widely distributed beta 1 integrins. Here we discuss the role of the cytoplasmic domains of leukocyte integrins and that of cytosolic proteins that bind integrins in mediating signal transduction. Distinct sites in the alpha as well as the common beta chain contribute to this process. We also show that beta 2 integrin distribution on the cell surface is of particular relevance for leukocytes to rapidly alter their adhesive state and display their highly dynamic adhesive behavior. From these and recently published findings the picture is arising that particular cell functions may be supported by integrin-specific signaling pathways.

KW - Amino Acid Sequence

KW - Animals

KW - Cell Adhesion/immunology

KW - Cytoplasm/chemistry

KW - Humans

KW - Integrins/genetics

KW - Leukocytes/chemistry

KW - Molecular Sequence Data

KW - Signal Transduction/immunology

M3 - Review article

VL - 6

SP - 247

EP - 254

JO - Cell adhesion and communication

JF - Cell adhesion and communication

SN - 1023-7046

IS - 2-3

ER -