Advanced detection of coronary artery disease with multimodality imaging: Exploring the relationship between coronary stenosis, plaque morphology and flow

Research output: PhD ThesisPhd-Thesis - Research and graduation internal


Because coronary artery disease (CAD) remains a leading cause of global morbidity and mortality, a careful diagnostic workup of patients with suspected CAD continues to be of utmost importance. Invasive coronary angiography (ICA) is currently the reference standard for diagnosing obstructive CAD, especially in conjunction with invasive functional tests. However, because of the potential risks and costs related to ICA, current guidelines advocate to use non-invasive imaging as an initial test in patients with suspected CAD. Although, or perhaps partially because of, an ever increasing array of diagnostic tools are available for contemporary cardiologists, the diagnostic workup remains challenging. Therefore, this thesis investigates the diagnostic value of multiple established and novel imaging modalities when compared with invasive reference measurements. Furthermore, additional non-invasive imaging features are tested for a potential incremental diagnostic and prognostic value. Finally, this thesis explores the complex relationship between coronary stenosis, plaque morphology and flow in a non-invasive as well as invasive fashion.
Original languageEnglish
QualificationDoctor of Philosophy
  • Knaapen, Paul, Supervisor
  • van Rossum, A.C., Supervisor, External person
  • Raijmakers, P.G.H.M., Co-supervisor, External person
  • Danad, Ibrahim, Co-supervisor
Award date6 Apr 2023
Place of PublicationNaarden
Print ISBNs9789464589764
Publication statusPublished - 6 Apr 2023

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