Advances in vector-mediated gene transfer

Bruce J Baum, Corinne M Goldsmith, Marc R Kok, Beatrijs M Lodde, Norah M van Mello, Antonis Voutetakis, Jianghua Wang, Seiichi Yamano, Changyu Zheng

Research output: Contribution to journalReview articleAcademicpeer-review


Clinical applications of gene transfer technology initially targeted the treatment of inherited monogenetic disorders and cancers refractory to conventional therapies. Today, gene transfer approaches are being developed for most tissues and for multiple disorders including those affecting quality of life. The focus herein is eventual application of gene transfer technology for the management of organ-directed autoimmunity. A specific example is presented: Sjögren's syndrome and localized salivary gland gene transfer. The status of relevant pre-clinical gene transfer studies is reviewed, with an emphasis on use of adenoviral and adeno-associated viral vectors. Current limitations of effective organ-directed gene transfer are also discussed.

Original languageEnglish
Pages (from-to)145-9
Number of pages5
JournalImmunology Letters
Issue number2-3
Publication statusPublished - 15 Dec 2003

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