Alcohol consumption and arterial stiffness in men

Aafje Sierksma, Majon Muller, Yvonne T. Van Der Schouw, Diederick E. Grobbee, Henk F J Hendriks, Michiel L. Bots

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness. Design: A cross-sectional study. Setting: The male population of Utrecht. Participants: Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulse-wave velocity (PWV) measurement of the aorta. Results: There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a -0.77 m/s (95% confidence interval, -1.26 to -0.28), -0.57 m/s (95% confidence interval, -1.07 to -0.08) and -0.14 m/s (95% confidence interval, -0.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association. Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalJournal of Hypertension
Volume22
Issue number2
DOIs
Publication statusPublished - 1 Feb 2004

Cite this

Sierksma, A., Muller, M., Van Der Schouw, Y. T., Grobbee, D. E., Hendriks, H. F. J., & Bots, M. L. (2004). Alcohol consumption and arterial stiffness in men. Journal of Hypertension, 22(2), 357-362. https://doi.org/10.1097/00004872-200402000-00020
Sierksma, Aafje ; Muller, Majon ; Van Der Schouw, Yvonne T. ; Grobbee, Diederick E. ; Hendriks, Henk F J ; Bots, Michiel L. / Alcohol consumption and arterial stiffness in men. In: Journal of Hypertension. 2004 ; Vol. 22, No. 2. pp. 357-362.
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Sierksma, A, Muller, M, Van Der Schouw, YT, Grobbee, DE, Hendriks, HFJ & Bots, ML 2004, 'Alcohol consumption and arterial stiffness in men' Journal of Hypertension, vol. 22, no. 2, pp. 357-362. https://doi.org/10.1097/00004872-200402000-00020

Alcohol consumption and arterial stiffness in men. / Sierksma, Aafje; Muller, Majon; Van Der Schouw, Yvonne T.; Grobbee, Diederick E.; Hendriks, Henk F J; Bots, Michiel L.

In: Journal of Hypertension, Vol. 22, No. 2, 01.02.2004, p. 357-362.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Sierksma, Aafje

AU - Muller, Majon

AU - Van Der Schouw, Yvonne T.

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AU - Hendriks, Henk F J

AU - Bots, Michiel L.

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N2 - Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness. Design: A cross-sectional study. Setting: The male population of Utrecht. Participants: Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulse-wave velocity (PWV) measurement of the aorta. Results: There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a -0.77 m/s (95% confidence interval, -1.26 to -0.28), -0.57 m/s (95% confidence interval, -1.07 to -0.08) and -0.14 m/s (95% confidence interval, -0.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association. Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption.

AB - Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness. Design: A cross-sectional study. Setting: The male population of Utrecht. Participants: Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulse-wave velocity (PWV) measurement of the aorta. Results: There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a -0.77 m/s (95% confidence interval, -1.26 to -0.28), -0.57 m/s (95% confidence interval, -1.07 to -0.08) and -0.14 m/s (95% confidence interval, -0.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association. Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption.

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Sierksma A, Muller M, Van Der Schouw YT, Grobbee DE, Hendriks HFJ, Bots ML. Alcohol consumption and arterial stiffness in men. Journal of Hypertension. 2004 Feb 1;22(2):357-362. https://doi.org/10.1097/00004872-200402000-00020