Altered microRNA processing proteins in HPV-induced cancers

Barbara C Snoek, Iris Babion, Danijela Koppers-Lalic, Dirk M Pegtel, Renske Dm Steenbergen

Research output: Contribution to journalReview articleAcademicpeer-review


High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalCurrent opinion in virology
Early online date10 Aug 2019
Publication statusPublished - 1 Dec 2019

Cite this