Altered microRNA processing proteins in HPV-induced cancers

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalCurrent opinion in virology
Volume39
DOIs
Publication statusE-pub ahead of print - 10 Aug 2019

Cite this

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title = "Altered microRNA processing proteins in HPV-induced cancers",
abstract = "High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.",
author = "Snoek, {Barbara C} and Iris Babion and Danijela Koppers-Lalic and Pegtel, {Dirk M} and Steenbergen, {Renske Dm}",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2019",
month = "8",
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doi = "10.1016/j.coviro.2019.07.002",
language = "English",
volume = "39",
pages = "23--32",
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}

Altered microRNA processing proteins in HPV-induced cancers. / Snoek, Barbara C; Babion, Iris; Koppers-Lalic, Danijela; Pegtel, Dirk M; Steenbergen, Renske Dm.

In: Current opinion in virology, Vol. 39, 10.08.2019, p. 23-32.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Altered microRNA processing proteins in HPV-induced cancers

AU - Snoek, Barbara C

AU - Babion, Iris

AU - Koppers-Lalic, Danijela

AU - Pegtel, Dirk M

AU - Steenbergen, Renske Dm

N1 - Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2019/8/10

Y1 - 2019/8/10

N2 - High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.

AB - High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.

U2 - 10.1016/j.coviro.2019.07.002

DO - 10.1016/j.coviro.2019.07.002

M3 - Review article

VL - 39

SP - 23

EP - 32

JO - Current opinion in virology

JF - Current opinion in virology

SN - 1879-6257

ER -