Altered structural connectome in temporal lobe epilepsy

Matthew N DeSalvo, Linda Douw, Naoaki Tanaka, Claus Reinsberger, Steven M Stufflebeam

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To study differences in the whole-brain structural connectomes of patients with left temporal lobe epilepsy (TLE) and healthy control subjects.

MATERIALS AND METHODS: This study was approved by the institutional review board, and all individuals gave signed informed consent. Sixty-direction diffusion-tensor imaging and magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) magnetic resonance imaging volumes were analyzed in 24 patients with left TLE and in 24 healthy control subjects. MP-RAGE volumes were segmented into 1015 regions of interest (ROIs) spanning the entire brain. Deterministic white matter tractography was performed after voxelwise tensor calculation. Weighted structural connectivity matrices were generated by using the pairwise density of connecting fibers between ROIs. Graph theoretical measures of connectivity networks were compared between groups by using linear models with permutation testing.

RESULTS: Patients with TLE had 22%-45% reduced (P < .01) distant connectivity in the medial orbitofrontal cortex, temporal cortex, posterior cingulate cortex, and precuneus, compared with that in healthy subjects. However, local connectivity, as measured by means of network efficiency, was increased by 85%-270% (P < .01) in the medial and lateral frontal cortices, insular cortex, posterior cingulate cortex, precuneus, and occipital cortex in patients with TLE as compared with healthy subjects.

CONCLUSION: This study suggests that TLE involves altered structural connectivity in a network that reaches beyond the temporal lobe, especially in the default mode network.

Original languageEnglish
Pages (from-to)842-8
Number of pages7
JournalRadiology
Volume270
Issue number3
DOIs
Publication statusPublished - Mar 2014

Cite this

DeSalvo, M. N., Douw, L., Tanaka, N., Reinsberger, C., & Stufflebeam, S. M. (2014). Altered structural connectome in temporal lobe epilepsy. Radiology, 270(3), 842-8. https://doi.org/10.1148/radiol.13131044