Alternative sites of tumor development

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

This chapter discusses alternative routes of tumor development, either for a short-term drug screening assay or because the tumor type studied not be accepted by any route except the brain. Fresh tumor implants from surgical specimens, as well as fragments from human tumor xenografts, were analyzed upon subrenal capsule (SRC) implantation, either as control tumors or after treatment. A number of investigators have analyzed the SRC assay of first transplant generation tumors in normal mice for its predictive value for drugs to be active in a particular tumor type or even in an individual patient. Cell cultures of such tumor types were reported to have preferential growth in immunologically privileged sites, such as the brain. Tumor systems have been made available in which tumor cells are injected into the brain and treatment is instituted on designated schedules following the inoculation of the tumor cells.
Original languageEnglish
Title of host publicationThe Nude Mouse in Oncology Research
PublisherCRC Press
Pages81-88
ISBN (Electronic)0849365317
ISBN (Print)9781315898117
DOIs
Publication statusPublished - 2018

Publication series

NameThe Nude Mouse in Oncology Research

Cite this

Boven, E. (2018). Alternative sites of tumor development. In The Nude Mouse in Oncology Research (pp. 81-88). (The Nude Mouse in Oncology Research). CRC Press. https://doi.org/10.1201/9781351077217
Boven, Epie. / Alternative sites of tumor development. The Nude Mouse in Oncology Research. CRC Press, 2018. pp. 81-88 (The Nude Mouse in Oncology Research).
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Boven, E 2018, Alternative sites of tumor development. in The Nude Mouse in Oncology Research. The Nude Mouse in Oncology Research, CRC Press, pp. 81-88. https://doi.org/10.1201/9781351077217

Alternative sites of tumor development. / Boven, Epie.

The Nude Mouse in Oncology Research. CRC Press, 2018. p. 81-88 (The Nude Mouse in Oncology Research).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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Boven E. Alternative sites of tumor development. In The Nude Mouse in Oncology Research. CRC Press. 2018. p. 81-88. (The Nude Mouse in Oncology Research). https://doi.org/10.1201/9781351077217