Ammonia: what adult neurologists need to know

Rick Meijer, Umesh Vivekananda, Simona Balestrini, Matthew Walker, Robin Lachmann, Johannes Haeberle, Elaine Murphy*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Hyperammonaemia is often encountered in acute neurology and can be the cause of acute or chronic neurological symptoms. Patients with hyperammonaemia may present with seizures or encephalopathy, or may be entirely asymptomatic. The underlying causes are diverse but often straightforward to diagnose, although sometimes require specialist investigations. Haemodialysis or haemo(dia)filtration is the first-line treatment for acute severe hyperammonaemia (of any cause) in an adult. Here we discuss our approach to adult patients with hyperammonaemia identified by a neurologist.

Original languageEnglish
Article number002654
Pages (from-to)36-42
Number of pages7
JournalPractical neurology
Issue number1
Publication statusPublished - 1 Feb 2021

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