AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma

Bas Vaarwerk, Marinka L. F. Hol, Reineke A. Schoot, Willemijn B. Breunis, Maartje M. L. de Win, Henrike Westerveld, Raquel Davila Fajardo, Peerooz Saeed, Michiel W. van den Brekel, Bradley R. Pieters, Simon D. Strackee, Ludi E. Smeele, Johannes H. M. Merks

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background and purpose: Survival after relapse of head and neck rhabdomyosarcoma (HNRMS) after prior external beam radiotherapy (EBRT) is poor, since options for adequate local treatment are often lacking. In this study we describe our experience with salvage AMORE in patients with relapsed HNRMS after prior EBRT. Materials and methods: Patients with relapsed HNRMS after prior EBRT in which salvage AMORE treatment was considered feasible were analysed; this includes patients with parameningeal, head and neck non-parameningeal and orbital localization. AMORE treatment consisted of Ablative surgery, MOuld technique brachytherapy and surgical REconstruction. Results: In total 18 patients received salvage AMORE treatment; nine patients had relapsed parameningeal (PM) RMS, two patients had relapsed head and neck non-parameningeal RMS (HN-nonPM) and seven patients had relapsed orbital RMS. Local control rate was 67% and 5-year overall survival was 54% (95% confidence interval: 31–78%); 3/9 patients with PM RMS, 0/2 patients with HN-nonPM RMS and 6/7 patients with orbital RMS were alive after a median follow-up of 8.6 years. One patient with PM RMS survived more than 5 years after which he died from a secondary cancer. Six patients developed a local relapse (of which one patient also developed a distant metastasis) and two patients developed distant metastases. Conclusions: Salvage AMORE treatment is a feasible and effective local therapy approach even after prior EBRT. Since salvage AMORE treatment is sometimes the only curative option in patient with relapsed HNRMS, we encourage physicians to consider salvage AMORE treatment for patients with relapsed HNRMS after prior EBRT.
Original languageEnglish
Pages (from-to)21-26
JournalRadiotherapy and Oncology
Volume131
DOIs
Publication statusPublished - 2019
Externally publishedYes

Cite this

Vaarwerk, Bas ; Hol, Marinka L. F. ; Schoot, Reineke A. ; Breunis, Willemijn B. ; de Win, Maartje M. L. ; Westerveld, Henrike ; Fajardo, Raquel Davila ; Saeed, Peerooz ; van den Brekel, Michiel W. ; Pieters, Bradley R. ; Strackee, Simon D. ; Smeele, Ludi E. ; Merks, Johannes H. M. / AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma. In: Radiotherapy and Oncology. 2019 ; Vol. 131. pp. 21-26.
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title = "AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma",
abstract = "Background and purpose: Survival after relapse of head and neck rhabdomyosarcoma (HNRMS) after prior external beam radiotherapy (EBRT) is poor, since options for adequate local treatment are often lacking. In this study we describe our experience with salvage AMORE in patients with relapsed HNRMS after prior EBRT. Materials and methods: Patients with relapsed HNRMS after prior EBRT in which salvage AMORE treatment was considered feasible were analysed; this includes patients with parameningeal, head and neck non-parameningeal and orbital localization. AMORE treatment consisted of Ablative surgery, MOuld technique brachytherapy and surgical REconstruction. Results: In total 18 patients received salvage AMORE treatment; nine patients had relapsed parameningeal (PM) RMS, two patients had relapsed head and neck non-parameningeal RMS (HN-nonPM) and seven patients had relapsed orbital RMS. Local control rate was 67{\%} and 5-year overall survival was 54{\%} (95{\%} confidence interval: 31–78{\%}); 3/9 patients with PM RMS, 0/2 patients with HN-nonPM RMS and 6/7 patients with orbital RMS were alive after a median follow-up of 8.6 years. One patient with PM RMS survived more than 5 years after which he died from a secondary cancer. Six patients developed a local relapse (of which one patient also developed a distant metastasis) and two patients developed distant metastases. Conclusions: Salvage AMORE treatment is a feasible and effective local therapy approach even after prior EBRT. Since salvage AMORE treatment is sometimes the only curative option in patient with relapsed HNRMS, we encourage physicians to consider salvage AMORE treatment for patients with relapsed HNRMS after prior EBRT.",
author = "Bas Vaarwerk and Hol, {Marinka L. F.} and Schoot, {Reineke A.} and Breunis, {Willemijn B.} and {de Win}, {Maartje M. L.} and Henrike Westerveld and Fajardo, {Raquel Davila} and Peerooz Saeed and {van den Brekel}, {Michiel W.} and Pieters, {Bradley R.} and Strackee, {Simon D.} and Smeele, {Ludi E.} and Merks, {Johannes H. M.}",
year = "2019",
doi = "10.1016/j.radonc.2018.10.036",
language = "English",
volume = "131",
pages = "21--26",
journal = "Radiotherapy and Oncology",
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AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma. / Vaarwerk, Bas; Hol, Marinka L. F.; Schoot, Reineke A.; Breunis, Willemijn B.; de Win, Maartje M. L.; Westerveld, Henrike; Fajardo, Raquel Davila; Saeed, Peerooz; van den Brekel, Michiel W.; Pieters, Bradley R.; Strackee, Simon D.; Smeele, Ludi E.; Merks, Johannes H. M.

In: Radiotherapy and Oncology, Vol. 131, 2019, p. 21-26.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma

AU - Vaarwerk, Bas

AU - Hol, Marinka L. F.

AU - Schoot, Reineke A.

AU - Breunis, Willemijn B.

AU - de Win, Maartje M. L.

AU - Westerveld, Henrike

AU - Fajardo, Raquel Davila

AU - Saeed, Peerooz

AU - van den Brekel, Michiel W.

AU - Pieters, Bradley R.

AU - Strackee, Simon D.

AU - Smeele, Ludi E.

AU - Merks, Johannes H. M.

PY - 2019

Y1 - 2019

N2 - Background and purpose: Survival after relapse of head and neck rhabdomyosarcoma (HNRMS) after prior external beam radiotherapy (EBRT) is poor, since options for adequate local treatment are often lacking. In this study we describe our experience with salvage AMORE in patients with relapsed HNRMS after prior EBRT. Materials and methods: Patients with relapsed HNRMS after prior EBRT in which salvage AMORE treatment was considered feasible were analysed; this includes patients with parameningeal, head and neck non-parameningeal and orbital localization. AMORE treatment consisted of Ablative surgery, MOuld technique brachytherapy and surgical REconstruction. Results: In total 18 patients received salvage AMORE treatment; nine patients had relapsed parameningeal (PM) RMS, two patients had relapsed head and neck non-parameningeal RMS (HN-nonPM) and seven patients had relapsed orbital RMS. Local control rate was 67% and 5-year overall survival was 54% (95% confidence interval: 31–78%); 3/9 patients with PM RMS, 0/2 patients with HN-nonPM RMS and 6/7 patients with orbital RMS were alive after a median follow-up of 8.6 years. One patient with PM RMS survived more than 5 years after which he died from a secondary cancer. Six patients developed a local relapse (of which one patient also developed a distant metastasis) and two patients developed distant metastases. Conclusions: Salvage AMORE treatment is a feasible and effective local therapy approach even after prior EBRT. Since salvage AMORE treatment is sometimes the only curative option in patient with relapsed HNRMS, we encourage physicians to consider salvage AMORE treatment for patients with relapsed HNRMS after prior EBRT.

AB - Background and purpose: Survival after relapse of head and neck rhabdomyosarcoma (HNRMS) after prior external beam radiotherapy (EBRT) is poor, since options for adequate local treatment are often lacking. In this study we describe our experience with salvage AMORE in patients with relapsed HNRMS after prior EBRT. Materials and methods: Patients with relapsed HNRMS after prior EBRT in which salvage AMORE treatment was considered feasible were analysed; this includes patients with parameningeal, head and neck non-parameningeal and orbital localization. AMORE treatment consisted of Ablative surgery, MOuld technique brachytherapy and surgical REconstruction. Results: In total 18 patients received salvage AMORE treatment; nine patients had relapsed parameningeal (PM) RMS, two patients had relapsed head and neck non-parameningeal RMS (HN-nonPM) and seven patients had relapsed orbital RMS. Local control rate was 67% and 5-year overall survival was 54% (95% confidence interval: 31–78%); 3/9 patients with PM RMS, 0/2 patients with HN-nonPM RMS and 6/7 patients with orbital RMS were alive after a median follow-up of 8.6 years. One patient with PM RMS survived more than 5 years after which he died from a secondary cancer. Six patients developed a local relapse (of which one patient also developed a distant metastasis) and two patients developed distant metastases. Conclusions: Salvage AMORE treatment is a feasible and effective local therapy approach even after prior EBRT. Since salvage AMORE treatment is sometimes the only curative option in patient with relapsed HNRMS, we encourage physicians to consider salvage AMORE treatment for patients with relapsed HNRMS after prior EBRT.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058453621&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30773183

U2 - 10.1016/j.radonc.2018.10.036

DO - 10.1016/j.radonc.2018.10.036

M3 - Article

VL - 131

SP - 21

EP - 26

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

ER -