Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?

Niki S. Schoonenboom; Cees Mulder; Gerard J. Van Kamp; Sangita P. Mehta; Philip Scheltens; Marinus A. Blankenstein; Pankaj D. Mehta

doi:10.1002/ana.20508

Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?

Niki S. Schoonenboom^*, Cees Mulder, Gerard J. Van Kamp, Sangita P. Mehta, Philip Scheltens, Marinus A. Blankenstein, Pankaj D. Mehta

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Various C-terminally truncated amyloid β peptides (Aβ) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Aβ38, Aβ40, and Aβ42 were measured by enzyme-linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF Aβ42 levels was decreased in patients with AD, whereas CSF Aβ38 and Aβ40 levels were similar in patients with AD and control subjects. All three Aβ peptides were interrelated, particularly CSF Aβ38 and Aβ40. Diagnostic accuracy of CSF Aβ42 concentrations was not improved by applying the ratios of CSF Aβ42 to Aβ38 or Aβ40.

Original language	English
Pages (from-to)	139-142
Number of pages	4
Journal	Annals of Neurology
Volume	58
Issue number	1
DOIs	https://doi.org/10.1002/ana.20508
Publication status	Published - 1 Jul 2005

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abstract = "Various C-terminally truncated amyloid β peptides (Aβ) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Aβ38, Aβ40, and Aβ42 were measured by enzyme-linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF Aβ42 levels was decreased in patients with AD, whereas CSF Aβ38 and Aβ40 levels were similar in patients with AD and control subjects. All three Aβ peptides were interrelated, particularly CSF Aβ38 and Aβ40. Diagnostic accuracy of CSF Aβ42 concentrations was not improved by applying the ratios of CSF Aβ42 to Aβ38 or Aβ40.",

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AU - Mehta, Sangita P.

AU - Scheltens, Philip

AU - Blankenstein, Marinus A.

AU - Mehta, Pankaj D.

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Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?

Abstract

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