TY - JOUR
T1 - AMYLOID-β IS ASSOCIATED WITH THINNER CORTEX IN COGNITIVELY NORMAL OLDEST-OLD INDIVIDUALS
AU - Pelkmans, Wiesje
AU - Legdeur, Nienke
AU - Kate, Mara ten
AU - Yaqub, Maqsood M.
AU - Van Berckel, Bart N.M.
AU - Visser, Pieter Jelle
AU - Tijms, Betty M.
PY - 2019/7
Y1 - 2019/7
N2 - Background: Previous autopsy studies have demonstrated a high prevalence of widespread Alzheimer's disease (AD) pathology in individuals without dementia at high ages (>85y), which has raised doubts on the relationship of amyloid-β (Aβ) with dementia. In younger elderly (60-80y) without cognitive impairment, Aβ accumulation has been associated with subtle cognitive changes and cortical thinning. However, it remains unclear whether Aβ accumulation in oldest-old individuals with normal cognition is associated with changes in brain structure and cognitive functioning. We studied this using data from the EMIF-AD 90+ study. Methods: We selected 61 cognitively normal (CN) individuals from the EMIF-AD 90+ study, with available amyloid positron emission tomography (PET), and structural magnetic resonance imaging (MRI). Visual rating of the amyloid PET scan was used to classify the subjects as CN Aβ- (n=34) or CN Aβ+ (n=27). Cognitive performance on the Logical Delayed Memory test and MMSE were compared between groups. Subcortical volumes and cortical thickness measures in each ROI of FreeSurfer's Desikan-Killany atlas were calculated from 3T 3D-T1 images, and compared between groups using general linear models with Bonferroni correction and adjusted for age, and sex. Results: The individuals had a mean age of 93 years (range 88-102y), and 44% were rated as Aβ+. CN Aβ+ individuals had lower, but non-significant, memory scores and worse MMSE scores compared to the Aβ- group (Table1). Moreover, compared to the Aβ- group, CN individuals with Aβ+ showed thinner parahippocampal, rostral anterior cingulate, medial orbitofrontal, fusiform, superior temporal cortex, and smaller amygdala volume (pBonferroni
AB - Background: Previous autopsy studies have demonstrated a high prevalence of widespread Alzheimer's disease (AD) pathology in individuals without dementia at high ages (>85y), which has raised doubts on the relationship of amyloid-β (Aβ) with dementia. In younger elderly (60-80y) without cognitive impairment, Aβ accumulation has been associated with subtle cognitive changes and cortical thinning. However, it remains unclear whether Aβ accumulation in oldest-old individuals with normal cognition is associated with changes in brain structure and cognitive functioning. We studied this using data from the EMIF-AD 90+ study. Methods: We selected 61 cognitively normal (CN) individuals from the EMIF-AD 90+ study, with available amyloid positron emission tomography (PET), and structural magnetic resonance imaging (MRI). Visual rating of the amyloid PET scan was used to classify the subjects as CN Aβ- (n=34) or CN Aβ+ (n=27). Cognitive performance on the Logical Delayed Memory test and MMSE were compared between groups. Subcortical volumes and cortical thickness measures in each ROI of FreeSurfer's Desikan-Killany atlas were calculated from 3T 3D-T1 images, and compared between groups using general linear models with Bonferroni correction and adjusted for age, and sex. Results: The individuals had a mean age of 93 years (range 88-102y), and 44% were rated as Aβ+. CN Aβ+ individuals had lower, but non-significant, memory scores and worse MMSE scores compared to the Aβ- group (Table1). Moreover, compared to the Aβ- group, CN individuals with Aβ+ showed thinner parahippocampal, rostral anterior cingulate, medial orbitofrontal, fusiform, superior temporal cortex, and smaller amygdala volume (pBonferroni
UR - http://www.mendeley.com/research/amyloid%CE%B2-associated-thinner-cortex-cognitively-normal-oldestold-individuals
U2 - 10.1016/j.jalz.2019.06.3431
DO - 10.1016/j.jalz.2019.06.3431
M3 - Meeting Abstract
VL - 15
SP - P1104-P1105
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
SN - 1552-5260
IS - 7
ER -