An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)

Renske Kruizinga, Michael Scherer-Rath, Johannes B. AM Schilderman, Iris D. Hartog, Jacoba P. M. van der Loos, Hantie P. Kotzé, Anneke M. Westermann, Heinz-Josef Klümpen, Francesco Kortekaas, Cecile Grootscholten, Frans Bossink, Jolanda Schrama, Willem van de Vrande, Natascha A. WP Schrama, Willem Blokland, Filip Y. FL de Vos, Annemieke Kuin, Wim G. Meijer, Martijn G. H. van Oijen, Mirjam A. G. Sprangers & 1 others Hanneke W. M. van Laarhoven

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions. Aim: A structured reflection could improve patients’ quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being. Design: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time. Participants: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group. Results: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life (β = 0.52, adj. R 2 = 0.26) and satisfaction with life (β = 0.61, adj. R 2 = 0.37). Conclusion: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.
Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalPalliative Medicine
Volume33
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019
Externally publishedYes

Cite this

Kruizinga, Renske ; Scherer-Rath, Michael ; Schilderman, Johannes B. AM ; Hartog, Iris D. ; van der Loos, Jacoba P. M. ; Kotzé, Hantie P. ; Westermann, Anneke M. ; Klümpen, Heinz-Josef ; Kortekaas, Francesco ; Grootscholten, Cecile ; Bossink, Frans ; Schrama, Jolanda ; van de Vrande, Willem ; Schrama, Natascha A. WP ; Blokland, Willem ; de Vos, Filip Y. FL ; Kuin, Annemieke ; Meijer, Wim G. ; van Oijen, Martijn G. H. ; Sprangers, Mirjam A. G. ; van Laarhoven, Hanneke W. M. / An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study). In: Palliative Medicine. 2019 ; Vol. 33, No. 2. pp. 221-231.
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title = "An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)",
abstract = "Background: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions. Aim: A structured reflection could improve patients’ quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being. Design: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time. Participants: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group. Results: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life (β = 0.52, adj. R 2 = 0.26) and satisfaction with life (β = 0.61, adj. R 2 = 0.37). Conclusion: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.",
keywords = "Oncology, palliative care, randomized controlled trials, spiritual care, spiritual care givers, spirituality",
author = "Renske Kruizinga and Michael Scherer-Rath and Schilderman, {Johannes B. AM} and Hartog, {Iris D.} and {van der Loos}, {Jacoba P. M.} and Kotz{\'e}, {Hantie P.} and Westermann, {Anneke M.} and Heinz-Josef Kl{\"u}mpen and Francesco Kortekaas and Cecile Grootscholten and Frans Bossink and Jolanda Schrama and {van de Vrande}, Willem and Schrama, {Natascha A. WP} and Willem Blokland and {de Vos}, {Filip Y. FL} and Annemieke Kuin and Meijer, {Wim G.} and {van Oijen}, {Martijn G. H.} and Sprangers, {Mirjam A. G.} and {van Laarhoven}, {Hanneke W. M.}",
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Kruizinga, R, Scherer-Rath, M, Schilderman, JBAM, Hartog, ID, van der Loos, JPM, Kotzé, HP, Westermann, AM, Klümpen, H-J, Kortekaas, F, Grootscholten, C, Bossink, F, Schrama, J, van de Vrande, W, Schrama, NAWP, Blokland, W, de Vos, FYFL, Kuin, A, Meijer, WG, van Oijen, MGH, Sprangers, MAG & van Laarhoven, HWM 2019, 'An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)' Palliative Medicine, vol. 33, no. 2, pp. 221-231. https://doi.org/10.1177/0269216318816005

An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study). / Kruizinga, Renske; Scherer-Rath, Michael; Schilderman, Johannes B. AM; Hartog, Iris D.; van der Loos, Jacoba P. M.; Kotzé, Hantie P.; Westermann, Anneke M.; Klümpen, Heinz-Josef; Kortekaas, Francesco; Grootscholten, Cecile; Bossink, Frans; Schrama, Jolanda; van de Vrande, Willem; Schrama, Natascha A. WP; Blokland, Willem; de Vos, Filip Y. FL; Kuin, Annemieke; Meijer, Wim G.; van Oijen, Martijn G. H.; Sprangers, Mirjam A. G.; van Laarhoven, Hanneke W. M.

In: Palliative Medicine, Vol. 33, No. 2, 01.02.2019, p. 221-231.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)

AU - Kruizinga, Renske

AU - Scherer-Rath, Michael

AU - Schilderman, Johannes B. AM

AU - Hartog, Iris D.

AU - van der Loos, Jacoba P. M.

AU - Kotzé, Hantie P.

AU - Westermann, Anneke M.

AU - Klümpen, Heinz-Josef

AU - Kortekaas, Francesco

AU - Grootscholten, Cecile

AU - Bossink, Frans

AU - Schrama, Jolanda

AU - van de Vrande, Willem

AU - Schrama, Natascha A. WP

AU - Blokland, Willem

AU - de Vos, Filip Y. FL

AU - Kuin, Annemieke

AU - Meijer, Wim G.

AU - van Oijen, Martijn G. H.

AU - Sprangers, Mirjam A. G.

AU - van Laarhoven, Hanneke W. M.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions. Aim: A structured reflection could improve patients’ quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being. Design: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time. Participants: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group. Results: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life (β = 0.52, adj. R 2 = 0.26) and satisfaction with life (β = 0.61, adj. R 2 = 0.37). Conclusion: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.

AB - Background: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions. Aim: A structured reflection could improve patients’ quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being. Design: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time. Participants: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group. Results: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life (β = 0.52, adj. R 2 = 0.26) and satisfaction with life (β = 0.61, adj. R 2 = 0.37). Conclusion: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.

KW - Oncology

KW - palliative care

KW - randomized controlled trials

KW - spiritual care

KW - spiritual care givers

KW - spirituality

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30516096

U2 - 10.1177/0269216318816005

DO - 10.1177/0269216318816005

M3 - Article

VL - 33

SP - 221

EP - 231

JO - Palliative Medicine

JF - Palliative Medicine

SN - 0269-2163

IS - 2

ER -