TY - JOUR
T1 - Ancestral and environmental patterns in the association between triglycerides and other cardiometabolic risk factors
AU - Meeks, Karlijn A. C.
AU - Bentley, Amy R.
AU - Agyemang, Charles
AU - Galenkamp, Henrike
AU - van den Born, Bert-Jan H.
AU - Hanssen, Nordin M. J.
AU - Doumatey, Ayo P.
AU - Adeyemo, Adebowale A.
AU - Rotimi, Charles N.
N1 - Funding Information:
Support for participant recruitment of the AADM study was provided by NIH grant No. 3T37TW00041-03S2 from the Office of Research on Minority Health. The RODAM study was funded by the European Commission under the Seventh Framework Program (grant number 278901 ). The HELIUS study is conducted by the Amsterdam University Medical Centers , location (AMC) and the Public Health Services (GGD) of Amsterdam. Both organizations provided core support for HELIUS. Additional funding has been granted by the Dutch Heart Foundation ( 2010T084 ), the Netherlands Organization for Health Research and Development (ZonMw) ( 200500003 ), and the European Fund for the Integration of non-EU immigrants (2013EIF013). The National Health and Nutrition Examination Survey (NHANES) is conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention and receives additional funding from various agencies of the U.S. Government. KACM, ARB, APD, AAA, and CNR are supported by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health (NIH) through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is also supported by the National Institute of Diabetes and Digestive and Kidney Diseases and the Office of the Director, NIH ( Z01HG200362 ). NMJH is supported by a Senior Clinical Dekker grant by the Dutch Heart Foundation (grant number 2021T055 ) and a DFN-DON grant 2020 (Grant number 2020.10.002).
Funding Information:
National Institutes of Health, European Commission, Dutch Heart Foundation, Netherlands Organization for Health Research and Development, Centers for Disease Control and Prevention.Support for participant recruitment of the AADM study was provided by NIH grant No. 3T37TW00041-03S2 from the Office of Research on Minority Health. The RODAM study was funded by the European Commission under the Seventh Framework Program (grant number 278901). The HELIUS study is conducted by the Amsterdam University Medical Centers, location (AMC) and the Public Health Services (GGD) of Amsterdam. Both organizations provided core support for HELIUS. Additional funding has been granted by the Dutch Heart Foundation (2010T084), the Netherlands Organization for Health Research and Development (ZonMw) (200500003), and the European Fund for the Integration of non-EU immigrants (2013EIF013). The National Health and Nutrition Examination Survey (NHANES) is conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention and receives additional funding from various agencies of the U.S. Government. KACM, ARB, APD, AAA, and CNR are supported by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health (NIH) through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is also supported by the National Institute of Diabetes and Digestive and Kidney Diseases and the Office of the Director, NIH (Z01HG200362). NMJH is supported by a Senior Clinical Dekker grant by the Dutch Heart Foundation (grant number 2021T055) and a DFN-DON grant 2020 (Grant number 2020.10.002). The authors are grateful to the Africa America Diabetes Mellitus (AADM) study, the Healthy Life in an Urban Setting (HELIUS) study, and the Research on Obesity and Diabetes among African Migrants (RODAM) study collaborators, management team, and advisory board members for their valuable support in shaping the methods of these studies. We are most grateful to the participants of the four studies included, research nurses, interviewers, research assistants, and other staff who have taken part in collecting the data. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Institutes of Health (NIH).
Publisher Copyright:
© 2023
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Background: West Africans and African Americans with substantial (∼80%) West African ancestry are characterized by low levels of triglycerides (TG) compared to East Africans and Europeans. The impact of these varying TG levels on other cardiometabolic risk factors is unclear. We compared the strength of association between TG with hypertension, blood pressure, BMI, waist circumference, type 2 diabetes (T2D), and fasting glucose across West African (WA), East African (EA), and European (EU) ancestry populations residing in three vastly different environmental settings: sub-Saharan Africa, United States, and Europe. Methods: We analysed data from four cross-sectional studies that included WA in sub-Saharan Africa (n = 7201), the U.S. (n = 4390), and Europe (n = 6436), EA in sub-Saharan Africa (n = 781), and EU in the U.S. (n = 8670) and Europe (n = 4541). Linear regression analyses were used to test the association between TG and cardiometabolic risk factors. Findings: Higher adjusted regression coefficients were observed in EU compared with WA ancestry for TG on hypertension (EU β [95% CI]: 0.179 [0.156, 0.203], WA β [95% CI]: 0.102 [0.086, 0.118]), BMI (EU β [95% CI]: 0.028 [0.027, 0.030], WA β [95% CI]: 0.015 [0.014, 0.016]), and waist circumference (EU β [95% CI]: 0.013 [0.013, 0.014], WA β [95% CI]: 0.009 [0.008, 0.009) (all ancestry × trait interaction P-values <0.05), irrespective of environmental differences within ancestry groups. Less consistency was observed among EA. Associations of TG with T2D did not follow ancestry patterns, with substantial variation observed between environments. Interpretation: TG may not be an equally strong associated with other established cardiometabolic risk factors in West and East Africans in contrast to European ancestry populations. The value of TG for identifying individuals at high risk for developing metabolic disorders needs to be re-evaluated for African ancestry populations. Funding: National Institutes of Health, European Commission, Dutch Heart Foundation, Netherlands Organization for Health Research and Development, Centers for Disease Control and Prevention.
AB - Background: West Africans and African Americans with substantial (∼80%) West African ancestry are characterized by low levels of triglycerides (TG) compared to East Africans and Europeans. The impact of these varying TG levels on other cardiometabolic risk factors is unclear. We compared the strength of association between TG with hypertension, blood pressure, BMI, waist circumference, type 2 diabetes (T2D), and fasting glucose across West African (WA), East African (EA), and European (EU) ancestry populations residing in three vastly different environmental settings: sub-Saharan Africa, United States, and Europe. Methods: We analysed data from four cross-sectional studies that included WA in sub-Saharan Africa (n = 7201), the U.S. (n = 4390), and Europe (n = 6436), EA in sub-Saharan Africa (n = 781), and EU in the U.S. (n = 8670) and Europe (n = 4541). Linear regression analyses were used to test the association between TG and cardiometabolic risk factors. Findings: Higher adjusted regression coefficients were observed in EU compared with WA ancestry for TG on hypertension (EU β [95% CI]: 0.179 [0.156, 0.203], WA β [95% CI]: 0.102 [0.086, 0.118]), BMI (EU β [95% CI]: 0.028 [0.027, 0.030], WA β [95% CI]: 0.015 [0.014, 0.016]), and waist circumference (EU β [95% CI]: 0.013 [0.013, 0.014], WA β [95% CI]: 0.009 [0.008, 0.009) (all ancestry × trait interaction P-values <0.05), irrespective of environmental differences within ancestry groups. Less consistency was observed among EA. Associations of TG with T2D did not follow ancestry patterns, with substantial variation observed between environments. Interpretation: TG may not be an equally strong associated with other established cardiometabolic risk factors in West and East Africans in contrast to European ancestry populations. The value of TG for identifying individuals at high risk for developing metabolic disorders needs to be re-evaluated for African ancestry populations. Funding: National Institutes of Health, European Commission, Dutch Heart Foundation, Netherlands Organization for Health Research and Development, Centers for Disease Control and Prevention.
KW - African
KW - Ancestry
KW - Environment
KW - European
KW - Triglycerides
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151259439&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/37004336
U2 - 10.1016/j.ebiom.2023.104548
DO - 10.1016/j.ebiom.2023.104548
M3 - Article
C2 - 37004336
SN - 2352-3964
VL - 91
JO - EBioMedicine
JF - EBioMedicine
M1 - 104548
ER -