Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate

H. J. De Voogt*, B. R. Rao, A. A. Geldof, L. J.G. Gooren, F. G. Bouman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of feminization appeared. Prostate volumes (measured by ultrasound) before and following Anandron treatment remained the same. After 18 months of treatment with cyproterone‐acetate and ethinyl estradiol, prostate volumes again were not changed. However, histology revealed glandular atrophy and an increase in stromal tissue. The significance of these findings is discussed.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalThe Prostate
Volume11
Issue number4
DOIs
Publication statusPublished - 1 Jan 1987

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