Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns

Anne Rifkin-Graboi, Michael J Meaney, Helen Chen, Jordan Bai, Waseem Bak'r Hameed, Mya Thway Tint, Birit F P Broekman, Yap-Seng Chong, Peter D Gluckman, Marielle V Fortier, Anqi Qiu

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: Antenatal maternal anxiety predicts offspring neurodevelopment and psychopathology, although the degree to which these associations reflect postnatal influences is unclear. To limit this possibility, we assessed newborn neuronal microstructures using diffusion tensor imaging (DTI) and assessed neonatal microstructure variation in relation to antenatal anxiety and in prediction of infant socio-emotional behavior at age 1 year.

METHOD: Dyads were drawn from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort, and included mothers who completed the Speilberger State-Trait Anxiety Inventory (STAI) at 26 weeks gestation (scoring >90, n = 20; scoring <70, n = 34) and their neonates (5-17 days postnatal) who took part in DTI.

RESULTS: Antenatal anxiety predicted variation in fractional anisotropy (FA) of regions important to cognitive-emotional responses to stress (i.e., the right insula and dorsolateral prefrontal cortex), sensory processing (e.g., right middle occipital), and socio-emotional function (e.g., the right angular gyrus, uncinate fasciculus, posterior cingulate, and parahippocampus). In a subset of infants with Infant Toddler Socio-Emotional Assessment (ITSEA) data, some of these right lateralized clusters predicted infant internalizing (e.g., insula: β = 0.511, p = .03) but not externalizing behavior 1 year later, although these analyses failed to withstand the correction for multiple comparisons.

CONCLUSION: These findings suggest the need for larger-scale investigations of the role that corticolimbic structures play in regulating cognitive-emotional responses to threat, and potentially in mediating the cross-generational transmission of anxiety, as well as in underscoring the importance of early mother-infant intervention programs.

Original languageEnglish
Pages (from-to)313-21.e2
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume54
Issue number4
DOIs
Publication statusPublished - Apr 2015
Externally publishedYes

Cite this

Rifkin-Graboi, Anne ; Meaney, Michael J ; Chen, Helen ; Bai, Jordan ; Hameed, Waseem Bak'r ; Tint, Mya Thway ; Broekman, Birit F P ; Chong, Yap-Seng ; Gluckman, Peter D ; Fortier, Marielle V ; Qiu, Anqi. / Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2015 ; Vol. 54, No. 4. pp. 313-21.e2.
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title = "Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns",
abstract = "OBJECTIVE: Antenatal maternal anxiety predicts offspring neurodevelopment and psychopathology, although the degree to which these associations reflect postnatal influences is unclear. To limit this possibility, we assessed newborn neuronal microstructures using diffusion tensor imaging (DTI) and assessed neonatal microstructure variation in relation to antenatal anxiety and in prediction of infant socio-emotional behavior at age 1 year.METHOD: Dyads were drawn from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort, and included mothers who completed the Speilberger State-Trait Anxiety Inventory (STAI) at 26 weeks gestation (scoring >90, n = 20; scoring <70, n = 34) and their neonates (5-17 days postnatal) who took part in DTI.RESULTS: Antenatal anxiety predicted variation in fractional anisotropy (FA) of regions important to cognitive-emotional responses to stress (i.e., the right insula and dorsolateral prefrontal cortex), sensory processing (e.g., right middle occipital), and socio-emotional function (e.g., the right angular gyrus, uncinate fasciculus, posterior cingulate, and parahippocampus). In a subset of infants with Infant Toddler Socio-Emotional Assessment (ITSEA) data, some of these right lateralized clusters predicted infant internalizing (e.g., insula: β = 0.511, p = .03) but not externalizing behavior 1 year later, although these analyses failed to withstand the correction for multiple comparisons.CONCLUSION: These findings suggest the need for larger-scale investigations of the role that corticolimbic structures play in regulating cognitive-emotional responses to threat, and potentially in mediating the cross-generational transmission of anxiety, as well as in underscoring the importance of early mother-infant intervention programs.",
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author = "Anne Rifkin-Graboi and Meaney, {Michael J} and Helen Chen and Jordan Bai and Hameed, {Waseem Bak'r} and Tint, {Mya Thway} and Broekman, {Birit F P} and Yap-Seng Chong and Gluckman, {Peter D} and Fortier, {Marielle V} and Anqi Qiu",
note = "Copyright {\circledC} 2015 American Academy of Child and Adolescent Psychiatry. All rights reserved.",
year = "2015",
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doi = "10.1016/j.jaac.2015.01.013",
language = "English",
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Rifkin-Graboi, A, Meaney, MJ, Chen, H, Bai, J, Hameed, WB, Tint, MT, Broekman, BFP, Chong, Y-S, Gluckman, PD, Fortier, MV & Qiu, A 2015, 'Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns' Journal of the American Academy of Child and Adolescent Psychiatry, vol. 54, no. 4, pp. 313-21.e2. https://doi.org/10.1016/j.jaac.2015.01.013

Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns. / Rifkin-Graboi, Anne; Meaney, Michael J; Chen, Helen; Bai, Jordan; Hameed, Waseem Bak'r; Tint, Mya Thway; Broekman, Birit F P; Chong, Yap-Seng; Gluckman, Peter D; Fortier, Marielle V; Qiu, Anqi.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 54, No. 4, 04.2015, p. 313-21.e2.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns

AU - Rifkin-Graboi, Anne

AU - Meaney, Michael J

AU - Chen, Helen

AU - Bai, Jordan

AU - Hameed, Waseem Bak'r

AU - Tint, Mya Thway

AU - Broekman, Birit F P

AU - Chong, Yap-Seng

AU - Gluckman, Peter D

AU - Fortier, Marielle V

AU - Qiu, Anqi

N1 - Copyright © 2015 American Academy of Child and Adolescent Psychiatry. All rights reserved.

PY - 2015/4

Y1 - 2015/4

N2 - OBJECTIVE: Antenatal maternal anxiety predicts offspring neurodevelopment and psychopathology, although the degree to which these associations reflect postnatal influences is unclear. To limit this possibility, we assessed newborn neuronal microstructures using diffusion tensor imaging (DTI) and assessed neonatal microstructure variation in relation to antenatal anxiety and in prediction of infant socio-emotional behavior at age 1 year.METHOD: Dyads were drawn from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort, and included mothers who completed the Speilberger State-Trait Anxiety Inventory (STAI) at 26 weeks gestation (scoring >90, n = 20; scoring <70, n = 34) and their neonates (5-17 days postnatal) who took part in DTI.RESULTS: Antenatal anxiety predicted variation in fractional anisotropy (FA) of regions important to cognitive-emotional responses to stress (i.e., the right insula and dorsolateral prefrontal cortex), sensory processing (e.g., right middle occipital), and socio-emotional function (e.g., the right angular gyrus, uncinate fasciculus, posterior cingulate, and parahippocampus). In a subset of infants with Infant Toddler Socio-Emotional Assessment (ITSEA) data, some of these right lateralized clusters predicted infant internalizing (e.g., insula: β = 0.511, p = .03) but not externalizing behavior 1 year later, although these analyses failed to withstand the correction for multiple comparisons.CONCLUSION: These findings suggest the need for larger-scale investigations of the role that corticolimbic structures play in regulating cognitive-emotional responses to threat, and potentially in mediating the cross-generational transmission of anxiety, as well as in underscoring the importance of early mother-infant intervention programs.

AB - OBJECTIVE: Antenatal maternal anxiety predicts offspring neurodevelopment and psychopathology, although the degree to which these associations reflect postnatal influences is unclear. To limit this possibility, we assessed newborn neuronal microstructures using diffusion tensor imaging (DTI) and assessed neonatal microstructure variation in relation to antenatal anxiety and in prediction of infant socio-emotional behavior at age 1 year.METHOD: Dyads were drawn from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort, and included mothers who completed the Speilberger State-Trait Anxiety Inventory (STAI) at 26 weeks gestation (scoring >90, n = 20; scoring <70, n = 34) and their neonates (5-17 days postnatal) who took part in DTI.RESULTS: Antenatal anxiety predicted variation in fractional anisotropy (FA) of regions important to cognitive-emotional responses to stress (i.e., the right insula and dorsolateral prefrontal cortex), sensory processing (e.g., right middle occipital), and socio-emotional function (e.g., the right angular gyrus, uncinate fasciculus, posterior cingulate, and parahippocampus). In a subset of infants with Infant Toddler Socio-Emotional Assessment (ITSEA) data, some of these right lateralized clusters predicted infant internalizing (e.g., insula: β = 0.511, p = .03) but not externalizing behavior 1 year later, although these analyses failed to withstand the correction for multiple comparisons.CONCLUSION: These findings suggest the need for larger-scale investigations of the role that corticolimbic structures play in regulating cognitive-emotional responses to threat, and potentially in mediating the cross-generational transmission of anxiety, as well as in underscoring the importance of early mother-infant intervention programs.

KW - Anisotropy

KW - Anxiety/physiopathology

KW - Anxiety Disorders/diagnosis

KW - Brain/pathology

KW - Depression

KW - Diffusion Tensor Imaging

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Linear Models

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Male

KW - Mothers/psychology

KW - Pregnancy

KW - Pregnancy Complications/psychology

KW - Prenatal Exposure Delayed Effects

KW - Psychiatric Status Rating Scales

KW - Singapore

U2 - 10.1016/j.jaac.2015.01.013

DO - 10.1016/j.jaac.2015.01.013

M3 - Article

VL - 54

SP - 313-21.e2

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 4

ER -