Antibody response to viral proteins u (vpu) and r (vpr) in HIV-1-infected individuals

Peter Reiss, Joep M.A. Lange, Anthony De Ronde, Frank De Wolf, John Dekker, Sven A. Danner, Christine Debouck, Jaap Goudsmit*

*Corresponding author for this work

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Antibodies to E. coli-produced HIV-1 vpr and vpu were determined by enzyme immunoassay in serial sets of sera from 72 men seroconverting for antibodies to HIV-1 structural proteins, and from 196 initially symptom-free men who were positive for such antibodies at study entry. First detection of vpr- and vpu-specific antibodies always was within 12 months of seroconversion for antibodies to structural proteins. In the combined cohort of 268 men, vpr- and vpu-specific antibodies were found persistently in 26 and 43% of men, respectively. Vpr- and vpu-specific antibodies were transiently detected in 3 and 7%, respectively, and intermittently detected in 18 and 13% of men. Vpr- and vpw-specific antibodies were not detected in 53 and 37% of men, respectively. No association was found between the patterns of vpr- or vpu-specific antibody response and clinical outcome. In subjects with different patterns of vpr- and vpu-specific antibody response, no clear temporal relationship existed between the appearance or disappearance of antibodies and the onset of HIV-1-related disease.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number2
Publication statusPublished - 1990

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