Antigen presentation to CD8+ T cells: cross-priming in infectious diseases

J M den Haan, M J Bevan

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.

Original languageEnglish
Pages (from-to)437-41
Number of pages5
JournalCurrent Opinion in Immunology
Volume13
Issue number4
Publication statusPublished - Aug 2001

Cite this

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title = "Antigen presentation to CD8+ T cells: cross-priming in infectious diseases",
abstract = "Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.",
keywords = "Animals, Antigen Presentation, Antigen-Presenting Cells/immunology, Apoptosis/immunology, CD8-Positive T-Lymphocytes/immunology, Communicable Diseases/immunology, Dendritic Cells/immunology, Humans, Necrosis",
author = "{den Haan}, {J M} and Bevan, {M J}",
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journal = "Current Opinion in Immunology",
issn = "0952-7915",
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Antigen presentation to CD8+ T cells : cross-priming in infectious diseases. / den Haan, J M; Bevan, M J.

In: Current Opinion in Immunology, Vol. 13, No. 4, 08.2001, p. 437-41.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Antigen presentation to CD8+ T cells

T2 - cross-priming in infectious diseases

AU - den Haan, J M

AU - Bevan, M J

PY - 2001/8

Y1 - 2001/8

N2 - Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.

AB - Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.

KW - Animals

KW - Antigen Presentation

KW - Antigen-Presenting Cells/immunology

KW - Apoptosis/immunology

KW - CD8-Positive T-Lymphocytes/immunology

KW - Communicable Diseases/immunology

KW - Dendritic Cells/immunology

KW - Humans

KW - Necrosis

M3 - Review article

VL - 13

SP - 437

EP - 441

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 4

ER -