Antigen presentation to CD8+ T cells: cross-priming in infectious diseases

J M den Haan, M J Bevan

Research output: Contribution to journalReview articleAcademicpeer-review


Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.

Original languageEnglish
Pages (from-to)437-41
Number of pages5
JournalCurrent Opinion in Immunology
Issue number4
Publication statusPublished - Aug 2001

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