Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.
|Journal||International journal of pharmaceutical compounding|
|Publication status||Published - 2018|
Breukels, O., van der Gronde, T., Simons-Sanders, K., & Crul, M. (2018). Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags. International journal of pharmaceutical compounding, 22(4), 345-349.