@article{823b40acc07544568a2dbdf139906d29,
title = "APOE and immunity: Research highlights",
abstract = "INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.",
keywords = "APOE, Alzheimer's disease, TREM2, amyloid beta, astrocytes, biomarkers, dementia, inflammation, microglia, neurodegeneration, neuroglia, neuroinflammation, tau",
author = "Kloske, {Courtney M.} and Barnum, {Christopher J.} and Batista, {Andre F.} and Bradshaw, {Elizabeth M.} and Brickman, {Adam M.} and Guojun Bu and Jessica Dennison and Gearon, {Mary D.} and Goate, {Alison M.} and Christian Haass and Heneka, {Michael T.} and Hu, {William T.} and Huggins, {Lenique K. L.} and Jones, {Nahdia S.} and Radosveta Koldamova and Lemere, {Cynthia A.} and Liddelow, {Shane A.} and Edoardo Marcora and Marsh, {Samuel E.} and Nielsen, {Henrietta M.} and Petersen, {Kellen K.} and Melissa Petersen and Pi{\~n}a-Escudero, {Stefanie D.} and Qiu, {Wei Qiao} and Quiroz, {Yakeel T.} and Eric Reiman and Claire Sexton and Tansey, {Mal{\'u} G. mez} and Julia Tcw and Teunissen, {Charlotte E.} and Tijms, {Betty M.} and {van der Kant}, Rik and Rebecca Wallings and Weninger, {Stacie C.} and Whitney Wharton and Wilcock, {Donna M.} and Wishard, {Tyler James} and Worley, {Susan L.} and Henrik Zetterberg and Carrillo, {Maria C.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
year = "2023",
doi = "10.1002/alz.13020",
language = "English",
journal = "Alzheimers & Dementia",
issn = "1552-5260",
publisher = "Elsevier",
}