APOE-ε4 allele for the diagnosis of Alzheimer's and other dementia disorders in people with mild cognitive impairment in a secondary care setting

Lyzel S. Elias-Sonnenschein*, Wolfgang Viechtbauer, Inez Ramakers, Obioha Ukoumunne, Frans R.J. Verhey, Pieter Jelle Visser

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: Our primary objective is to determine the diagnostic accuracy of the APOE-ε4 allele in detecting AD dementia and other types of dementia in people with MCI in a secondary care setting. Our secondary objective is to investigate the following potential sources of heterogeneity of test accuracy, where reported: characteristics of participants, namely, baseline MMSE score, age, and gender; APOE-ε4 background prevalence; MCI definition; length of follow-up; and reference standards.

Original languageEnglish
Article numberCD010950
JournalCochrane Database of Systematic Reviews
Volume2014
Issue number1
DOIs
Publication statusPublished - 31 Jan 2014

Cite this