Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

IMBI Brain Imaging Working Group, Daniela Perani, Leonardo Iaccarino, Andreas H. Jacobs, Adriaan A. Lammertsma, Agneta Nordberg, Albert D. Windhorst, Alexander Gerhard, Alexandra Winkeler, Anthony Gee, Bertrand Kuhnast, Christer Halldin, David Brooks, Elena Rodriguez-Vieitez, Federico E. Turkheimer, Francisco López-Picón, Gitte M. Knudsen, Johnny Vercouillie, Juha O. Rinne, Karl Herholz & 11 others Koen van Laere, Marie Joao Santiago-Ribeiro, Matthias M. Herth, Michael A. Carroll, Michel Bottlaender, Oskar Hansson, Paul Edison, Rainer Hinz, Ronald Boellaard, Rosa Maria Moresco, Sabina Pappata

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
LanguageEnglish
Pages327-332
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
Publication statusPublished - 2019

Cite this

@article{0c5545b964874b039458b4a188c9664a,
title = "Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies",
abstract = "Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.",
author = "{IMBI Brain Imaging Working Group} and Daniela Perani and Leonardo Iaccarino and Jacobs, {Andreas H.} and Lammertsma, {Adriaan A.} and Agneta Nordberg and Windhorst, {Albert D.} and Alexander Gerhard and Alexandra Winkeler and Anthony Gee and Bertrand Kuhnast and Christer Halldin and David Brooks and Elena Rodriguez-Vieitez and Turkheimer, {Federico E.} and Francisco L{\'o}pez-Pic{\'o}n and Knudsen, {Gitte M.} and Johnny Vercouillie and Rinne, {Juha O.} and Karl Herholz and {van Laere}, Koen and Santiago-Ribeiro, {Marie Joao} and Herth, {Matthias M.} and Carroll, {Michael A.} and Michel Bottlaender and Oskar Hansson and Paul Edison and Rainer Hinz and Ronald Boellaard and Moresco, {Rosa Maria} and Sabina Pappata",
year = "2019",
doi = "10.1016/j.dadm.2019.02.004",
language = "English",
volume = "11",
pages = "327--332",
journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",
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Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies. / IMBI Brain Imaging Working Group.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 2019, p. 327-332.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

AU - IMBI Brain Imaging Working Group

AU - Perani, Daniela

AU - Iaccarino, Leonardo

AU - Jacobs, Andreas H.

AU - Lammertsma, Adriaan A.

AU - Nordberg, Agneta

AU - Windhorst, Albert D.

AU - Gerhard, Alexander

AU - Winkeler, Alexandra

AU - Gee, Anthony

AU - Kuhnast, Bertrand

AU - Halldin, Christer

AU - Brooks, David

AU - Rodriguez-Vieitez, Elena

AU - Turkheimer, Federico E.

AU - López-Picón, Francisco

AU - Knudsen, Gitte M.

AU - Vercouillie, Johnny

AU - Rinne, Juha O.

AU - Herholz, Karl

AU - van Laere, Koen

AU - Santiago-Ribeiro, Marie Joao

AU - Herth, Matthias M.

AU - Carroll, Michael A.

AU - Bottlaender, Michel

AU - Hansson, Oskar

AU - Edison, Paul

AU - Hinz, Rainer

AU - Boellaard, Ronald

AU - Moresco, Rosa Maria

AU - Pappata, Sabina

PY - 2019

Y1 - 2019

N2 - Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

AB - Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

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EP - 332

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

SN - 2352-8729

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