Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

IMBI Brain Imaging Working Group

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
Original languageEnglish
Pages (from-to)327-332
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
Publication statusPublished - 2019

Cite this

@article{0c5545b964874b039458b4a188c9664a,
title = "Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies",
abstract = "Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.",
author = "{IMBI Brain Imaging Working Group} and Daniela Perani and Leonardo Iaccarino and Jacobs, {Andreas H.} and Lammertsma, {Adriaan A.} and Agneta Nordberg and Windhorst, {Albert D.} and Alexander Gerhard and Alexandra Winkeler and Anthony Gee and Bertrand Kuhnast and Christer Halldin and David Brooks and Elena Rodriguez-Vieitez and Turkheimer, {Federico E.} and Francisco L{\'o}pez-Pic{\'o}n and Knudsen, {Gitte M.} and Johnny Vercouillie and Rinne, {Juha O.} and Karl Herholz and {van Laere}, Koen and Santiago-Ribeiro, {Marie Joao} and Herth, {Matthias M.} and Carroll, {Michael A.} and Michel Bottlaender and Oskar Hansson and Paul Edison and Rainer Hinz and Ronald Boellaard and Moresco, {Rosa Maria} and Sabina Pappata",
year = "2019",
doi = "10.1016/j.dadm.2019.02.004",
language = "English",
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pages = "327--332",
journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",
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Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies. / IMBI Brain Imaging Working Group.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 2019, p. 327-332.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

AU - IMBI Brain Imaging Working Group

AU - Perani, Daniela

AU - Iaccarino, Leonardo

AU - Jacobs, Andreas H.

AU - Lammertsma, Adriaan A.

AU - Nordberg, Agneta

AU - Windhorst, Albert D.

AU - Gerhard, Alexander

AU - Winkeler, Alexandra

AU - Gee, Anthony

AU - Kuhnast, Bertrand

AU - Halldin, Christer

AU - Brooks, David

AU - Rodriguez-Vieitez, Elena

AU - Turkheimer, Federico E.

AU - López-Picón, Francisco

AU - Knudsen, Gitte M.

AU - Vercouillie, Johnny

AU - Rinne, Juha O.

AU - Herholz, Karl

AU - van Laere, Koen

AU - Santiago-Ribeiro, Marie Joao

AU - Herth, Matthias M.

AU - Carroll, Michael A.

AU - Bottlaender, Michel

AU - Hansson, Oskar

AU - Edison, Paul

AU - Hinz, Rainer

AU - Boellaard, Ronald

AU - Moresco, Rosa Maria

AU - Pappata, Sabina

PY - 2019

Y1 - 2019

N2 - Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

AB - Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

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EP - 332

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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SN - 2352-8729

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