Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Lorna Ewart; Eva-Maria Dehne; Kristin Fabre; Susan Gibbs; James Hickman; Ellinor Hornberg; Magnus Ingelman-Sundberg; Kyung-Jin Jang; David R. Jones; Volker M. Lauschke; Uwe Marx; Jerome T. Mettetal; Amy Pointon; Dominic Williams; Wolfram-Hubertus Zimmermann; Peter Newham

doi:10.1146/annurev-pharmtox-010617-052722

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Lorna Ewart, Eva-Maria Dehne, Kristin Fabre, Susan Gibbs, James Hickman, Ellinor Hornberg, Magnus Ingelman-Sundberg, Kyung-Jin Jang, David R. Jones, Volker M. Lauschke, Uwe Marx, Jerome T. Mettetal, Amy Pointon, Dominic Williams, Wolfram-Hubertus Zimmermann, Peter Newham

Molecular cell biology and Immunology

Research output: Contribution to journal › Review article › Academic › peer-review

Original language	English
Pages (from-to)	65-82
Journal	Annual Review of Pharmacology and Toxicology
Volume	58
DOIs	https://doi.org/10.1146/annurev-pharmtox-010617-052722
Publication status	Published - 2018

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10.1146/annurev-pharmtox-010617-052722

Cite this

Ewart, L., Dehne, E-M., Fabre, K., Gibbs, S., Hickman, J., Hornberg, E., Ingelman-Sundberg, M., Jang, K-J., Jones, D. R., Lauschke, V. M., Marx, U., Mettetal, J. T., Pointon, A., Williams, D., Zimmermann, W-H., & Newham, P. (2018). Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Annual Review of Pharmacology and Toxicology, 58, 65-82. https://doi.org/10.1146/annurev-pharmtox-010617-052722

Ewart, Lorna ; Dehne, Eva-Maria ; Fabre, Kristin ; Gibbs, Susan ; Hickman, James ; Hornberg, Ellinor ; Ingelman-Sundberg, Magnus ; Jang, Kyung-Jin ; Jones, David R. ; Lauschke, Volker M. ; Marx, Uwe ; Mettetal, Jerome T. ; Pointon, Amy ; Williams, Dominic ; Zimmermann, Wolfram-Hubertus ; Newham, Peter. / Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. In: Annual Review of Pharmacology and Toxicology. 2018 ; Vol. 58. pp. 65-82.

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title = "Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery",

keywords = "microphysiological systems, toxicology, drug discovery",

author = "Lorna Ewart and Eva-Maria Dehne and Kristin Fabre and Susan Gibbs and James Hickman and Ellinor Hornberg and Magnus Ingelman-Sundberg and Kyung-Jin Jang and Jones, {David R.} and Lauschke, {Volker M.} and Uwe Marx and Mettetal, {Jerome T.} and Amy Pointon and Dominic Williams and Wolfram-Hubertus Zimmermann and Peter Newham",

year = "2018",

doi = "10.1146/annurev-pharmtox-010617-052722",

language = "English",

volume = "58",

pages = "65--82",

journal = "Annual Review of Pharmacology and Toxicology",

issn = "0362-1642",

publisher = "Annual Reviews Inc.",

}

Ewart, L, Dehne, E-M, Fabre, K, Gibbs, S, Hickman, J, Hornberg, E, Ingelman-Sundberg, M, Jang, K-J, Jones, DR, Lauschke, VM, Marx, U, Mettetal, JT, Pointon, A, Williams, D, Zimmermann, W-H & Newham, P 2018, 'Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery', Annual Review of Pharmacology and Toxicology, vol. 58, pp. 65-82. https://doi.org/10.1146/annurev-pharmtox-010617-052722

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. / Ewart, Lorna; Dehne, Eva-Maria; Fabre, Kristin; Gibbs, Susan; Hickman, James; Hornberg, Ellinor; Ingelman-Sundberg, Magnus; Jang, Kyung-Jin; Jones, David R.; Lauschke, Volker M.; Marx, Uwe; Mettetal, Jerome T.; Pointon, Amy; Williams, Dominic; Zimmermann, Wolfram-Hubertus; Newham, Peter.

In: Annual Review of Pharmacology and Toxicology, Vol. 58, 2018, p. 65-82.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

AU - Ewart, Lorna

AU - Dehne, Eva-Maria

AU - Fabre, Kristin

AU - Gibbs, Susan

AU - Hickman, James

AU - Hornberg, Ellinor

AU - Ingelman-Sundberg, Magnus

AU - Jang, Kyung-Jin

AU - Jones, David R.

AU - Lauschke, Volker M.

AU - Marx, Uwe

AU - Mettetal, Jerome T.

AU - Pointon, Amy

AU - Williams, Dominic

AU - Zimmermann, Wolfram-Hubertus

AU - Newham, Peter

PY - 2018

Y1 - 2018

KW - microphysiological systems

KW - toxicology

KW - drug discovery

U2 - 10.1146/annurev-pharmtox-010617-052722

DO - 10.1146/annurev-pharmtox-010617-052722

M3 - Review article

C2 - 29029591

VL - 58

SP - 65

EP - 82

JO - Annual Review of Pharmacology and Toxicology

JF - Annual Review of Pharmacology and Toxicology

SN - 0362-1642

ER -