TY - JOUR
T1 - Are early measured resting-state EEG parameters predictive for upper limb motor impairment six months poststroke?
AU - Saes, Mique
AU - Meskers, Carel G.M.
AU - Daffertshofer, Andreas
AU - van Wegen, Erwin E.H.
AU - Kwakkel, Gert
PY - 2021/1
Y1 - 2021/1
N2 - Objectives: Investigate whether resting-state EEG parameters recorded early poststroke can predict upper extremity motor impairment reflected by the Fugl-Meyer motor score (FM-UE) after six months, and whether they have prognostic value in addition to FM-UE at baseline. Methods: Quantitative EEG parameters delta/alpha ratio (DAR), brain symmetry index (BSI) and directional BSI (BSIdir) were derived from 62-channel resting-state EEG recordings in 39 adults within three weeks after a first-ever ischemic hemispheric stroke. FM-UE scores were acquired within three weeks (FM-UEbaseline) and at 26 weeks poststroke (FM-UEw26). Linear regression analyses were performed using a forward selection procedure to predict FM-UEw26. Results: BSI calculated over the theta band (BSItheta) (β = −0.40; p = 0.013) was the strongest EEG-based predictor regarding FM-UEw26. BSItheta (β = −0.27; p = 0.006) remained a significant predictor when added to a regression model including FM-UEbaseline, increasing explained variance from 61.5% to 68.1%. Conclusion: Higher BSItheta values, reflecting more power asymmetry over the hemispheres, predict more upper limb motor impairment six months after stroke. Moreover, BSItheta shows additive prognostic value regarding FM-UEw26 next to FM-UEbaseline scores, and thereby contains unique information regarding upper extremity motor recovery. Significance: To our knowledge, we are the first to show that resting-state EEG parameters can serve as prognostic biomarkers of stroke recovery, in addition to FM-UEbaseline scores.
AB - Objectives: Investigate whether resting-state EEG parameters recorded early poststroke can predict upper extremity motor impairment reflected by the Fugl-Meyer motor score (FM-UE) after six months, and whether they have prognostic value in addition to FM-UE at baseline. Methods: Quantitative EEG parameters delta/alpha ratio (DAR), brain symmetry index (BSI) and directional BSI (BSIdir) were derived from 62-channel resting-state EEG recordings in 39 adults within three weeks after a first-ever ischemic hemispheric stroke. FM-UE scores were acquired within three weeks (FM-UEbaseline) and at 26 weeks poststroke (FM-UEw26). Linear regression analyses were performed using a forward selection procedure to predict FM-UEw26. Results: BSI calculated over the theta band (BSItheta) (β = −0.40; p = 0.013) was the strongest EEG-based predictor regarding FM-UEw26. BSItheta (β = −0.27; p = 0.006) remained a significant predictor when added to a regression model including FM-UEbaseline, increasing explained variance from 61.5% to 68.1%. Conclusion: Higher BSItheta values, reflecting more power asymmetry over the hemispheres, predict more upper limb motor impairment six months after stroke. Moreover, BSItheta shows additive prognostic value regarding FM-UEw26 next to FM-UEbaseline scores, and thereby contains unique information regarding upper extremity motor recovery. Significance: To our knowledge, we are the first to show that resting-state EEG parameters can serve as prognostic biomarkers of stroke recovery, in addition to FM-UEbaseline scores.
KW - Biomarker
KW - EEG
KW - Prediction
KW - Recovery of function
KW - Stroke
KW - Upper extremity
UR - http://www.scopus.com/inward/record.url?scp=85096854161&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2020.09.031
DO - 10.1016/j.clinph.2020.09.031
M3 - Article
C2 - 33248434
AN - SCOPUS:85096854161
VL - 132
SP - 56
EP - 62
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 1
ER -