Are omphalocele and neural tube defects related congenital anomalies?: Data from 21 registries in europe (EUROCAT)

E. Calzolari; F. Bianchi; H. Dolk; D. Stone; M. Milan; M. Lechat; P. Leurquin; S. Goyens; G. Astolfi; S. Volpato; S. Aymé; A. Calabro; M. Clementi; R. Tenconi; M. Cornel; A. Cuschieri; S. Garcia-Minaur; E. Garne; Y. Gillerot; J. Goujard; D. Hansen-Koening; M. Roulleaux; P. J. Howard; Z. Johnson; D. F. Lillis; N. C. Nevin; V. Nelen; T. Pexieder; A. Pierini; C. Stoll; I. Svel

doi:10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R

Are omphalocele and neural tube defects related congenital anomalies? Data from 21 registries in europe (EUROCAT)

E. Calzolari^*, F. Bianchi, H. Dolk, D. Stone, M. Milan, M. Lechat, P. Leurquin, S. Goyens, G. Astolfi, S. Volpato, S. Aymé, A. Calabro, M. Clementi, R. Tenconi, M. Cornel, A. Cuschieri, S. Garcia-Minaur, E. Garne, Y. Gillerot, J. GoujardD. Hansen-Koening, M. Roulleaux, P. J. Howard, Z. Johnson, D. F. Lillis, N. C. Nevin, V. Nelen, T. Pexieder, A. Pierini, C. Stoll, I. Svel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We have analyzed the association between omphalocele and neural tube defects (O/NTD) previously reported in epidemiological studies of EUROCAT registry data [Dolk et al., 1991; Calzolari et al., 1995]. By examining differences in prevalence between the United Kingdom and Ireland (UKI) and Continental Europe and Malta (CEM) and differences in sex ratio, the possible etiopathogenetic differences between O/NTD association and omphalocele without NTD and NTD without omphalocele were investigated. The distribution of O/NTD cases according to NTD site in the two geographic areas shows in the UKI a tendency for omphalocele to associate with anencephaly/spina bifida and with anencephaly. In CEM centers, these types of NTD are much rarer. The pattern of other anomalies occurring in combination with O/NTD association in the same babies was also analysed.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	American Journal of Medical Genetics
Volume	72
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R
Publication status	Published - 3 Oct 1997
Externally published	Yes

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10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R

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Calzolari, E., Bianchi, F., Dolk, H., Stone, D., Milan, M., Lechat, M., Leurquin, P., Goyens, S., Astolfi, G., Volpato, S., Aymé, S., Calabro, A., Clementi, M., Tenconi, R., Cornel, M., Cuschieri, A., Garcia-Minaur, S., Garne, E., Gillerot, Y., ... Svel, I. (1997). Are omphalocele and neural tube defects related congenital anomalies? Data from 21 registries in europe (EUROCAT). American Journal of Medical Genetics, 72(1), 79-84. https://doi.org/10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R

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title = "Are omphalocele and neural tube defects related congenital anomalies?: Data from 21 registries in europe (EUROCAT)",

abstract = "We have analyzed the association between omphalocele and neural tube defects (O/NTD) previously reported in epidemiological studies of EUROCAT registry data [Dolk et al., 1991; Calzolari et al., 1995]. By examining differences in prevalence between the United Kingdom and Ireland (UKI) and Continental Europe and Malta (CEM) and differences in sex ratio, the possible etiopathogenetic differences between O/NTD association and omphalocele without NTD and NTD without omphalocele were investigated. The distribution of O/NTD cases according to NTD site in the two geographic areas shows in the UKI a tendency for omphalocele to associate with anencephaly/spina bifida and with anencephaly. In CEM centers, these types of NTD are much rarer. The pattern of other anomalies occurring in combination with O/NTD association in the same babies was also analysed.",

keywords = "Congenital anomalies, Etiology, NTD, Omphalocele",

author = "E. Calzolari and F. Bianchi and H. Dolk and D. Stone and M. Milan and M. Lechat and P. Leurquin and S. Goyens and G. Astolfi and S. Volpato and S. Aym{\'e} and A. Calabro and M. Clementi and R. Tenconi and M. Cornel and A. Cuschieri and S. Garcia-Minaur and E. Garne and Y. Gillerot and J. Goujard and D. Hansen-Koening and M. Roulleaux and Howard, {P. J.} and Z. Johnson and Lillis, {D. F.} and Nevin, {N. C.} and V. Nelen and T. Pexieder and A. Pierini and C. Stoll and I. Svel",

year = "1997",

month = oct,

day = "3",

doi = "10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R",

language = "English",

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journal = "American Journal of Medical Genetics Part A",

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Calzolari, E, Bianchi, F, Dolk, H, Stone, D, Milan, M, Lechat, M, Leurquin, P, Goyens, S, Astolfi, G, Volpato, S, Aymé, S, Calabro, A, Clementi, M, Tenconi, R, Cornel, M, Cuschieri, A, Garcia-Minaur, S, Garne, E, Gillerot, Y, Goujard, J, Hansen-Koening, D, Roulleaux, M, Howard, PJ, Johnson, Z, Lillis, DF, Nevin, NC, Nelen, V, Pexieder, T, Pierini, A, Stoll, C & Svel, I 1997, 'Are omphalocele and neural tube defects related congenital anomalies? Data from 21 registries in europe (EUROCAT)', American Journal of Medical Genetics, vol. 72, no. 1, pp. 79-84. https://doi.org/10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R

TY - JOUR

T1 - Are omphalocele and neural tube defects related congenital anomalies?

T2 - Data from 21 registries in europe (EUROCAT)

AU - Calzolari, E.

AU - Bianchi, F.

AU - Dolk, H.

AU - Stone, D.

AU - Milan, M.

AU - Lechat, M.

AU - Leurquin, P.

AU - Goyens, S.

AU - Astolfi, G.

AU - Volpato, S.

AU - Aymé, S.

AU - Calabro, A.

AU - Clementi, M.

AU - Tenconi, R.

AU - Cornel, M.

AU - Cuschieri, A.

AU - Garcia-Minaur, S.

AU - Garne, E.

AU - Gillerot, Y.

AU - Goujard, J.

AU - Hansen-Koening, D.

AU - Roulleaux, M.

AU - Howard, P. J.

AU - Johnson, Z.

AU - Lillis, D. F.

AU - Nevin, N. C.

AU - Nelen, V.

AU - Pexieder, T.

AU - Pierini, A.

AU - Stoll, C.

AU - Svel, I.

PY - 1997/10/3

Y1 - 1997/10/3

N2 - We have analyzed the association between omphalocele and neural tube defects (O/NTD) previously reported in epidemiological studies of EUROCAT registry data [Dolk et al., 1991; Calzolari et al., 1995]. By examining differences in prevalence between the United Kingdom and Ireland (UKI) and Continental Europe and Malta (CEM) and differences in sex ratio, the possible etiopathogenetic differences between O/NTD association and omphalocele without NTD and NTD without omphalocele were investigated. The distribution of O/NTD cases according to NTD site in the two geographic areas shows in the UKI a tendency for omphalocele to associate with anencephaly/spina bifida and with anencephaly. In CEM centers, these types of NTD are much rarer. The pattern of other anomalies occurring in combination with O/NTD association in the same babies was also analysed.

AB - We have analyzed the association between omphalocele and neural tube defects (O/NTD) previously reported in epidemiological studies of EUROCAT registry data [Dolk et al., 1991; Calzolari et al., 1995]. By examining differences in prevalence between the United Kingdom and Ireland (UKI) and Continental Europe and Malta (CEM) and differences in sex ratio, the possible etiopathogenetic differences between O/NTD association and omphalocele without NTD and NTD without omphalocele were investigated. The distribution of O/NTD cases according to NTD site in the two geographic areas shows in the UKI a tendency for omphalocele to associate with anencephaly/spina bifida and with anencephaly. In CEM centers, these types of NTD are much rarer. The pattern of other anomalies occurring in combination with O/NTD association in the same babies was also analysed.

KW - Congenital anomalies

KW - Etiology

KW - NTD

KW - Omphalocele

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U2 - 10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R

DO - 10.1002/(SICI)1096-8628(19971003)72:1<79::AID-AJMG17>3.0.CO;2-R

M3 - Article

C2 - 9295081

AN - SCOPUS:0030928106

VL - 72

SP - 79

EP - 84

JO - American Journal of Medical Genetics Part A

JF - American Journal of Medical Genetics Part A

SN - 1552-4825

IS - 1

ER -

Are omphalocele and neural tube defects related congenital anomalies? Data from 21 registries in europe (EUROCAT)

Abstract

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