Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages

Alberto P. Avolio, Tatiana Kuznetsova, Guy R. Heyndrickx, Peter L. M. Kerkhof, John K. -J. Li

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

The increase in pulse pressure (PP) that occurs with advancing age is predominantly due to reduced arterial distensibility leading to decreased aortic compliance, particularly in the elderly, in whom high blood pressure mainly manifests as isolated systolic hypertension. Since age-related changes in stroke volume are minimal compared with changes in PP, PP is often considered a surrogate measure of arterial stiffness. However, since PP is determined by both cardiac and arterial function, a more precise and reliable means of assessment of arterial stiffness is arterial pulse wave velocity (PWV), a parameter that is only dependent on arterial properties. Arterial stiffness as measured by PWV has been found to be a powerful pressure-related indicator for cardiovascular morbidity and mortality. We analyzed PP and PWV in men and women of various age groups in healthy volunteers as well as cardiac patients with different types of diseases. The findings identified several striking sex-specific differences which demand consideration in guidelines for diagnostic procedures, for epidemiological analysis, and in evaluation of therapeutic interventions.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages153-168
Number of pages16
Volume1065
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Cite this

Avolio, A. P., Kuznetsova, T., Heyndrickx, G. R., Kerkhof, P. L. M., & Li, J. K. -J. (2018). Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages. In Advances in Experimental Medicine and Biology (Vol. 1065, pp. 153-168). (Advances in Experimental Medicine and Biology). Springer New York LLC. https://doi.org/10.1007/978-3-319-77932-4_10
Avolio, Alberto P. ; Kuznetsova, Tatiana ; Heyndrickx, Guy R. ; Kerkhof, Peter L. M. ; Li, John K. -J. / Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages. Advances in Experimental Medicine and Biology. Vol. 1065 Springer New York LLC, 2018. pp. 153-168 (Advances in Experimental Medicine and Biology).
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Avolio, AP, Kuznetsova, T, Heyndrickx, GR, Kerkhof, PLM & Li, JK-J 2018, Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages. in Advances in Experimental Medicine and Biology. vol. 1065, Advances in Experimental Medicine and Biology, Springer New York LLC, pp. 153-168. https://doi.org/10.1007/978-3-319-77932-4_10

Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages. / Avolio, Alberto P.; Kuznetsova, Tatiana; Heyndrickx, Guy R.; Kerkhof, Peter L. M.; Li, John K. -J.

Advances in Experimental Medicine and Biology. Vol. 1065 Springer New York LLC, 2018. p. 153-168 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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Avolio AP, Kuznetsova T, Heyndrickx GR, Kerkhof PLM, Li JK-J. Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages. In Advances in Experimental Medicine and Biology. Vol. 1065. Springer New York LLC. 2018. p. 153-168. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-77932-4_10