Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect

Alessandra Salvetti*, Andrea Degl'Innocenti, Gaetana Gambino, Jack J. W. A. van Loon, Chiara Ippolito, Sandra Ghelardoni, Eric Ghigo, Luca Leoncino, Mirko Prato, Leonardo Rossi, Gianni Ciofani*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particular, we provide a comprehensive evaluation of molecular responses in intact and regenerating specimens, and demonstrate a protective action from the space-apt for nanotechnological antioxidant cerium oxide nanoparticles.
Original languageEnglish
JournalJournal of Biomedical Materials Research Part A
Early online date2021
DOIs
Publication statusE-pub ahead of print - 2021

Cite this