Assessing bone development in preterm infants using quantitative ultrasonography showed a decline in the early postnatal period

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Abstract

Aim: Preterm infants have an insufficient bone mineral store at birth and this study explored their bone development during the early postnatal period. Methods: The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to assess bone development in 277 preterm infants, admitted to the neonatal intensive care unit of the VU University Medical Center, Amsterdam, the Netherlands from 2007-2012. Results: During the first nine postnatal weeks, the mcSOS declined from 10 to 38 m per second per week and the mcBTT declined from 20 to 71 nanoseconds per week. The pattern of change in both of these measurements showed a significant difference between infants born before 32 weeks of gestation (p = 0.048) and those born between 28 and 32 weeks of gestation (p = 0.008). There was a borderline significant difference in the pattern of change of the mcBTT in infants with a protein intake below 2 g/kg per day versus a higher intake (p = 0.050). Conclusion: The mcSOS and mcBTT of preterm infants showed a small to moderate decline during the early postnatal period. Future studies should explore the clinical relevance of this decline and develop interventions to halt it.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume107
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Cite this

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title = "Assessing bone development in preterm infants using quantitative ultrasonography showed a decline in the early postnatal period",
abstract = "Aim: Preterm infants have an insufficient bone mineral store at birth and this study explored their bone development during the early postnatal period. Methods: The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to assess bone development in 277 preterm infants, admitted to the neonatal intensive care unit of the VU University Medical Center, Amsterdam, the Netherlands from 2007-2012. Results: During the first nine postnatal weeks, the mcSOS declined from 10 to 38 m per second per week and the mcBTT declined from 20 to 71 nanoseconds per week. The pattern of change in both of these measurements showed a significant difference between infants born before 32 weeks of gestation (p = 0.048) and those born between 28 and 32 weeks of gestation (p = 0.008). There was a borderline significant difference in the pattern of change of the mcBTT in infants with a protein intake below 2 g/kg per day versus a higher intake (p = 0.050). Conclusion: The mcSOS and mcBTT of preterm infants showed a small to moderate decline during the early postnatal period. Future studies should explore the clinical relevance of this decline and develop interventions to halt it.",
keywords = "Bone mineral store, Metacarpal bone transmission time, Metacarpal speed of sound, Nutrition, Preterm infant",
author = "Marieke Krikke and Dana Yumani and Christine Rustenburg and Anneke Cranendonk and Jos Twisk and Harrie Lafeber and {van Weissenbruch}, Mirjam",
year = "2018",
month = "2",
day = "1",
doi = "10.1111/apa.14088",
language = "English",
volume = "107",
pages = "227--233",
journal = "Acta Paediatrica",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
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TY - JOUR

T1 - Assessing bone development in preterm infants using quantitative ultrasonography showed a decline in the early postnatal period

AU - Krikke, Marieke

AU - Yumani, Dana

AU - Rustenburg, Christine

AU - Cranendonk, Anneke

AU - Twisk, Jos

AU - Lafeber, Harrie

AU - van Weissenbruch, Mirjam

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Aim: Preterm infants have an insufficient bone mineral store at birth and this study explored their bone development during the early postnatal period. Methods: The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to assess bone development in 277 preterm infants, admitted to the neonatal intensive care unit of the VU University Medical Center, Amsterdam, the Netherlands from 2007-2012. Results: During the first nine postnatal weeks, the mcSOS declined from 10 to 38 m per second per week and the mcBTT declined from 20 to 71 nanoseconds per week. The pattern of change in both of these measurements showed a significant difference between infants born before 32 weeks of gestation (p = 0.048) and those born between 28 and 32 weeks of gestation (p = 0.008). There was a borderline significant difference in the pattern of change of the mcBTT in infants with a protein intake below 2 g/kg per day versus a higher intake (p = 0.050). Conclusion: The mcSOS and mcBTT of preterm infants showed a small to moderate decline during the early postnatal period. Future studies should explore the clinical relevance of this decline and develop interventions to halt it.

AB - Aim: Preterm infants have an insufficient bone mineral store at birth and this study explored their bone development during the early postnatal period. Methods: The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to assess bone development in 277 preterm infants, admitted to the neonatal intensive care unit of the VU University Medical Center, Amsterdam, the Netherlands from 2007-2012. Results: During the first nine postnatal weeks, the mcSOS declined from 10 to 38 m per second per week and the mcBTT declined from 20 to 71 nanoseconds per week. The pattern of change in both of these measurements showed a significant difference between infants born before 32 weeks of gestation (p = 0.048) and those born between 28 and 32 weeks of gestation (p = 0.008). There was a borderline significant difference in the pattern of change of the mcBTT in infants with a protein intake below 2 g/kg per day versus a higher intake (p = 0.050). Conclusion: The mcSOS and mcBTT of preterm infants showed a small to moderate decline during the early postnatal period. Future studies should explore the clinical relevance of this decline and develop interventions to halt it.

KW - Bone mineral store

KW - Metacarpal bone transmission time

KW - Metacarpal speed of sound

KW - Nutrition

KW - Preterm infant

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U2 - 10.1111/apa.14088

DO - 10.1111/apa.14088

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