TY - JOUR
T1 - Assessing everyday activities across the dementia spectrum with the amsterdam IADL questionnaire
AU - Facal, David
AU - Carabias, Miguel Angel Ruiz
AU - Pereiro, Arturo X.
AU - Lojo-Seoane, Cristina
AU - Campos-Magdaleno, María
AU - Jutten, Roos J.
AU - Sikkes, Sietske A. M.
AU - Juncos-Rabadán, Onésimo
PY - 2018
Y1 - 2018
N2 - Background: Instrumental activities of daily living (IADL) are complex activities which involve multiple cognitive processes, and which are expected to be susceptible to the early effects of cognitive impairment. Informant-based questionnaires are the most common tools used to assess IADL performance in dementia, but must be adjusted for use in early stages of impairment. Objective: To investigate the differences in IADL on the continuum of cognitive decline (i.e. no cognitive decline-subjective cognitive decline-mild cognitive impairment-mild dementia-moderate demen-tia) using the Spanish version of the Amsterdam IADL Questionnaire (A-IADL-Q). Methods: A total of 500 volunteer participants were included: 88 participants with no signs of cognitive decline, 109 participants with subjective cognitive complaints, 114 participants with mild cognitive impairment (MCI), 81 participants with mild dementia and 108 participants with moderate dementia. IADL was assessed with the A-IADL-Q, a computerized and adaptive questionnaire that calculates scores according to the specific pattern of responses of each participant. The data were examined by ANOVAs and regression analysis. Multinomial logistic regression analysis was used to evaluate the capacity of the A-IADL-Q to distinguish between diagnostic groups. Results: Participants with no cognitive decline and those with subjective cognitive decline obtained higher A-IADL-Q scores than MCI participants, and participants with MCI obtained higher scores than patients with dementia. The A-IADL-Q showed excellent discrimination between non-cognitive impairment and dementia, and significant but low discrimination between non-cognitive impairment and MCI. Conclusion: A-IADL-Q can discriminate IADL functioning between groups across the dementia spectrum.
AB - Background: Instrumental activities of daily living (IADL) are complex activities which involve multiple cognitive processes, and which are expected to be susceptible to the early effects of cognitive impairment. Informant-based questionnaires are the most common tools used to assess IADL performance in dementia, but must be adjusted for use in early stages of impairment. Objective: To investigate the differences in IADL on the continuum of cognitive decline (i.e. no cognitive decline-subjective cognitive decline-mild cognitive impairment-mild dementia-moderate demen-tia) using the Spanish version of the Amsterdam IADL Questionnaire (A-IADL-Q). Methods: A total of 500 volunteer participants were included: 88 participants with no signs of cognitive decline, 109 participants with subjective cognitive complaints, 114 participants with mild cognitive impairment (MCI), 81 participants with mild dementia and 108 participants with moderate dementia. IADL was assessed with the A-IADL-Q, a computerized and adaptive questionnaire that calculates scores according to the specific pattern of responses of each participant. The data were examined by ANOVAs and regression analysis. Multinomial logistic regression analysis was used to evaluate the capacity of the A-IADL-Q to distinguish between diagnostic groups. Results: Participants with no cognitive decline and those with subjective cognitive decline obtained higher A-IADL-Q scores than MCI participants, and participants with MCI obtained higher scores than patients with dementia. The A-IADL-Q showed excellent discrimination between non-cognitive impairment and dementia, and significant but low discrimination between non-cognitive impairment and MCI. Conclusion: A-IADL-Q can discriminate IADL functioning between groups across the dementia spectrum.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056279169&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30251604
U2 - 10.2174/1567205015666180925113411
DO - 10.2174/1567205015666180925113411
M3 - Article
C2 - 30251604
VL - 15
SP - 1261
EP - 1266
JO - Current Alzheimer Research
JF - Current Alzheimer Research
SN - 1567-2050
IS - 13
ER -