Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome

Emeline Crutcher; May Ali; John Harrison; Judit Sovago; Baltazar Gomez-Mancilla; Christian P. Schaaf

doi:10.1007/s10803-015-2694-0

Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome

Emeline Crutcher, May Ali, John Harrison, Judit Sovago, Baltazar Gomez-Mancilla, Christian P. Schaaf

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.

Original language	English
Pages (from-to)	1455-1463
Journal	Journal of Autism and Developmental Disorders
Volume	46
Issue number	4
DOIs	https://doi.org/10.1007/s10803-015-2694-0
Publication status	Published - Apr 2016

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10.1007/s10803-015-2694-0

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title = "Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome",

abstract = "15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.",

keywords = "Neuropsychiatric disease, Autism, Intellectual disability, Cognitive tests, Cognitive function",

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Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome. / Crutcher, Emeline; Ali, May; Harrison, John; Sovago, Judit; Gomez-Mancilla, Baltazar; Schaaf, Christian P.

In: Journal of Autism and Developmental Disorders, Vol. 46, No. 4, 04.2016, p. 1455-1463.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome

AU - Crutcher, Emeline

AU - Ali, May

AU - Harrison, John

AU - Sovago, Judit

AU - Gomez-Mancilla, Baltazar

AU - Schaaf, Christian P.

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N2 - 15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.

AB - 15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.

KW - Neuropsychiatric disease

KW - Autism

KW - Intellectual disability

KW - Cognitive tests

KW - Cognitive function

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JO - Journal of Autism and Developmental Disorders

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