TY - JOUR
T1 - Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome
AU - Crutcher, Emeline
AU - Ali, May
AU - Harrison, John
AU - Sovago, Judit
AU - Gomez-Mancilla, Baltazar
AU - Schaaf, Christian P.
PY - 2016/4
Y1 - 2016/4
N2 - 15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.
AB - 15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.
KW - Neuropsychiatric disease
KW - Autism
KW - Intellectual disability
KW - Cognitive tests
KW - Cognitive function
U2 - 10.1007/s10803-015-2694-0
DO - 10.1007/s10803-015-2694-0
M3 - Article
C2 - 26754479
VL - 46
SP - 1455
EP - 1463
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 4
ER -