Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Pradeep J. Nathan, Yen Ying Lim, Rosemary Abbott, Samantha Galluzzi, Moira Marizzoni, Claudio Babiloni, Diego Albani, David Bartres-Faz, Mira Didic, Lucia Farotti, Lucilla Parnetti, Nicola Salvadori, Bernhard W. Müller, Gianluigi Forloni, Nicola Girtler, Tilman Hensch, Jorge Jovicich, Annebet Leeuwis, Camillo Marra, José Luis Molinuevo & 15 others Flavio Nobili, Jeremie Pariente, Pierre Payoux, Jean Philippe Ranjeva, Elena Rolandi, Paolo Maria Rossini, Peter Schönknecht, Andrea Soricelli, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richardson, Régis Bordet, Olivier Blin, Giovanni B. Frisoni

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalNeurobiology of Aging
Volume53
DOIs
Publication statusPublished - 1 May 2017

Cite this

Nathan, Pradeep J. ; Lim, Yen Ying ; Abbott, Rosemary ; Galluzzi, Samantha ; Marizzoni, Moira ; Babiloni, Claudio ; Albani, Diego ; Bartres-Faz, David ; Didic, Mira ; Farotti, Lucia ; Parnetti, Lucilla ; Salvadori, Nicola ; Müller, Bernhard W. ; Forloni, Gianluigi ; Girtler, Nicola ; Hensch, Tilman ; Jovicich, Jorge ; Leeuwis, Annebet ; Marra, Camillo ; Molinuevo, José Luis ; Nobili, Flavio ; Pariente, Jeremie ; Payoux, Pierre ; Ranjeva, Jean Philippe ; Rolandi, Elena ; Rossini, Paolo Maria ; Schönknecht, Peter ; Soricelli, Andrea ; Tsolaki, Magda ; Visser, Pieter Jelle ; Wiltfang, Jens ; Richardson, Jill C. ; Bordet, Régis ; Blin, Olivier ; Frisoni, Giovanni B. / Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). In: Neurobiology of Aging. 2017 ; Vol. 53. pp. 1-10.
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title = "Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)",
abstract = "Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.",
keywords = "Alzheimer's disease, Amyloid, CANTAB, Cognitive assessment, CSF, Hippocampal volume, Mild cognitive impairment, Prodromal, Tau",
author = "Nathan, {Pradeep J.} and Lim, {Yen Ying} and Rosemary Abbott and Samantha Galluzzi and Moira Marizzoni and Claudio Babiloni and Diego Albani and David Bartres-Faz and Mira Didic and Lucia Farotti and Lucilla Parnetti and Nicola Salvadori and M{\"u}ller, {Bernhard W.} and Gianluigi Forloni and Nicola Girtler and Tilman Hensch and Jorge Jovicich and Annebet Leeuwis and Camillo Marra and Molinuevo, {Jos{\'e} Luis} and Flavio Nobili and Jeremie Pariente and Pierre Payoux and Ranjeva, {Jean Philippe} and Elena Rolandi and Rossini, {Paolo Maria} and Peter Sch{\"o}nknecht and Andrea Soricelli and Magda Tsolaki and Visser, {Pieter Jelle} and Jens Wiltfang and Richardson, {Jill C.} and R{\'e}gis Bordet and Olivier Blin and Frisoni, {Giovanni B.}",
year = "2017",
month = "5",
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Nathan, PJ, Lim, YY, Abbott, R, Galluzzi, S, Marizzoni, M, Babiloni, C, Albani, D, Bartres-Faz, D, Didic, M, Farotti, L, Parnetti, L, Salvadori, N, Müller, BW, Forloni, G, Girtler, N, Hensch, T, Jovicich, J, Leeuwis, A, Marra, C, Molinuevo, JL, Nobili, F, Pariente, J, Payoux, P, Ranjeva, JP, Rolandi, E, Rossini, PM, Schönknecht, P, Soricelli, A, Tsolaki, M, Visser, PJ, Wiltfang, J, Richardson, JC, Bordet, R, Blin, O & Frisoni, GB 2017, 'Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)' Neurobiology of Aging, vol. 53, pp. 1-10. https://doi.org/10.1016/j.neurobiolaging.2017.01.013

Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). / Nathan, Pradeep J.; Lim, Yen Ying; Abbott, Rosemary; Galluzzi, Samantha; Marizzoni, Moira; Babiloni, Claudio; Albani, Diego; Bartres-Faz, David; Didic, Mira; Farotti, Lucia; Parnetti, Lucilla; Salvadori, Nicola; Müller, Bernhard W.; Forloni, Gianluigi; Girtler, Nicola; Hensch, Tilman; Jovicich, Jorge; Leeuwis, Annebet; Marra, Camillo; Molinuevo, José Luis; Nobili, Flavio; Pariente, Jeremie; Payoux, Pierre; Ranjeva, Jean Philippe; Rolandi, Elena; Rossini, Paolo Maria; Schönknecht, Peter; Soricelli, Andrea; Tsolaki, Magda; Visser, Pieter Jelle; Wiltfang, Jens; Richardson, Jill C.; Bordet, Régis; Blin, Olivier; Frisoni, Giovanni B.

In: Neurobiology of Aging, Vol. 53, 01.05.2017, p. 1-10.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

AU - Nathan, Pradeep J.

AU - Lim, Yen Ying

AU - Abbott, Rosemary

AU - Galluzzi, Samantha

AU - Marizzoni, Moira

AU - Babiloni, Claudio

AU - Albani, Diego

AU - Bartres-Faz, David

AU - Didic, Mira

AU - Farotti, Lucia

AU - Parnetti, Lucilla

AU - Salvadori, Nicola

AU - Müller, Bernhard W.

AU - Forloni, Gianluigi

AU - Girtler, Nicola

AU - Hensch, Tilman

AU - Jovicich, Jorge

AU - Leeuwis, Annebet

AU - Marra, Camillo

AU - Molinuevo, José Luis

AU - Nobili, Flavio

AU - Pariente, Jeremie

AU - Payoux, Pierre

AU - Ranjeva, Jean Philippe

AU - Rolandi, Elena

AU - Rossini, Paolo Maria

AU - Schönknecht, Peter

AU - Soricelli, Andrea

AU - Tsolaki, Magda

AU - Visser, Pieter Jelle

AU - Wiltfang, Jens

AU - Richardson, Jill C.

AU - Bordet, Régis

AU - Blin, Olivier

AU - Frisoni, Giovanni B.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.

AB - Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.

KW - Alzheimer's disease

KW - Amyloid

KW - CANTAB

KW - Cognitive assessment

KW - CSF

KW - Hippocampal volume

KW - Mild cognitive impairment

KW - Prodromal

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=85012085428&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2017.01.013

DO - 10.1016/j.neurobiolaging.2017.01.013

M3 - Article

VL - 53

SP - 1

EP - 10

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -