Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 198-210 |
| Journal | The Lancet Neurology |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Feb 2019 |
Cite this
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Association between pathological and MRI findings in multiple sclerosis. / Filippi, Massimo; Brück, Wolfgang; Chard, Declan; Fazekas, Franz; Geurts, Jeroen J. G.; Enzinger, Christian; Hametner, Simon; Kuhlmann, Tanja; Preziosa, Paolo; Rovira, Àlex; Schmierer, Klaus; Stadelmann, Christine; Rocca, Maria A.; Attendees of the Correlation between Pathological and MRI findings in MS workshop.
In: The Lancet Neurology, Vol. 18, No. 2, 01.02.2019, p. 198-210.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Association between pathological and MRI findings in multiple sclerosis
AU - Filippi, Massimo
AU - Brück, Wolfgang
AU - Chard, Declan
AU - Fazekas, Franz
AU - Geurts, Jeroen J. G.
AU - Enzinger, Christian
AU - Hametner, Simon
AU - Kuhlmann, Tanja
AU - Preziosa, Paolo
AU - Rovira, Àlex
AU - Schmierer, Klaus
AU - Stadelmann, Christine
AU - Rocca, Maria A.
AU - Attendees of the Correlation between Pathological and MRI findings in MS workshop
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Pathological evaluation is the gold standard for identifying processes related to multiple sclerosis that explain disease manifestations, and for guiding the development of new treatments. However, there are limitations to the techniques used, including the small number of donors available, samples often representing uncommon cases, and impossibility of follow-up. Correlative studies have demonstrated that MRI is sensitive to the different pathological substrates of multiple sclerosis (inflammation, demyelination, and neuro-axonal loss). The role of MRI in evaluating other pathological processes, such as leptomeningeal involvement, central vein and rim of lesions, microstructural abnormalities, iron accumulation, and recovery mechanisms, has been investigated. Although techniques used for quantifying pathological processes in different regions of the CNS have advanced diagnosis and monitoring of disease course and treatment of multiple sclerosis, new perspectives and questions have emerged, including how different pathological processes interact over the disease course and when remyelination might occur. Addressing these questions will require longitudinal studies using MRI in large cohorts of patients with different phenotypes.
AB - Pathological evaluation is the gold standard for identifying processes related to multiple sclerosis that explain disease manifestations, and for guiding the development of new treatments. However, there are limitations to the techniques used, including the small number of donors available, samples often representing uncommon cases, and impossibility of follow-up. Correlative studies have demonstrated that MRI is sensitive to the different pathological substrates of multiple sclerosis (inflammation, demyelination, and neuro-axonal loss). The role of MRI in evaluating other pathological processes, such as leptomeningeal involvement, central vein and rim of lesions, microstructural abnormalities, iron accumulation, and recovery mechanisms, has been investigated. Although techniques used for quantifying pathological processes in different regions of the CNS have advanced diagnosis and monitoring of disease course and treatment of multiple sclerosis, new perspectives and questions have emerged, including how different pathological processes interact over the disease course and when remyelination might occur. Addressing these questions will require longitudinal studies using MRI in large cohorts of patients with different phenotypes.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060030193&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30663609
U2 - 10.1016/S1474-4422(18)30451-4
DO - 10.1016/S1474-4422(18)30451-4
M3 - Review article
VL - 18
SP - 198
EP - 210
JO - Lancet Neurology
JF - Lancet Neurology
SN - 1474-4422
IS - 2
ER -