TY - JOUR
T1 - Association of cardiovascular risk burden with risk of dementia and brain pathologies
T2 - A population-based cohort study
AU - Song, Ruixue
AU - Pan, Kuan-Yu
AU - Xu, Hui
AU - Qi, Xiuying
AU - Buchman, Aron S
AU - Bennett, David A
AU - Xu, Weili
N1 - Funding Information:
The authors express their gratitude to the participants and staff involved in data collection and management in the Rush Memory and Aging Project. Weili Xu received grants from the Swedish Research Council (No. 2017‐00981), the National Natural Science Foundation of China (No. 81771519), Demensfonden, the Konung Gustaf V:s och Drottning Victorias Frimurare Foundation (No. 2016‐2020), and Alzheimerfonden (2017‐2019). Bennett received grants from the National Institutes of Health (No. R01AG17917 and UH2NS100599). This project is part of CoSTREAM ( www.costream.eu ) and received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 667375.
Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2021
Y1 - 2021
N2 - INTRODUCTION: The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.METHODS: Within the Rush Memory and Aging Project, 1588 dementia-free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow-up, 621 participants died and underwent autopsies.RESULTS: The multi-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00-1.07) for dementia and 1.04 (1.01-1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02-1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03-1.17), and global AD pathology (OR 1.06, 95% CI 1.01-1.12).CONCLUSIONS: A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.
AB - INTRODUCTION: The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.METHODS: Within the Rush Memory and Aging Project, 1588 dementia-free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow-up, 621 participants died and underwent autopsies.RESULTS: The multi-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00-1.07) for dementia and 1.04 (1.01-1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02-1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03-1.17), and global AD pathology (OR 1.06, 95% CI 1.01-1.12).CONCLUSIONS: A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.
KW - Alzheimer's disease dementia
KW - Framingham General Cardiovascular Risk Score
KW - brain pathology
KW - cohort study
KW - dementia
UR - http://www.scopus.com/inward/record.url?scp=85111459743&partnerID=8YFLogxK
U2 - 10.1002/alz.12343
DO - 10.1002/alz.12343
M3 - Article
C2 - 34310004
SN - 1552-5260
VL - 17
SP - 1914
EP - 1922
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
IS - 12
ER -