Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

IMI DIRECT Consortium

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.
Original languageEnglish
Article numbere3063
JournalDiabetes/Metabolism Research and Reviews
Volume34
Issue number8
DOIs
Publication statusPublished - 2018

Cite this

@article{c9f9949e957545cbb64574cb12a33c27,
title = "Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study",
abstract = "Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-{\ss}). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-{\ss} while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.",
keywords = "Glycemic deterioration, HbA1c, Inflammation, Insulin resistance, {\ss}-cell function",
author = "{IMI DIRECT Consortium} and {de las Heras Gala}, Tonia and Christian Herder and Femke Rutters and Maren Carstensen-Kirberg and Cornelia Huth and Stehouwer, {Coen D. A.} and Giel Nijpels and Casper Schalkwijk and Allan Flyvbjerg and Franks, {Paul W.} and Jacqueline Dekker and Christa Meisinger and Wolfgang Koenig and Michael Roden and Wolfgang Rathmann and Annette Peters and Barbara Thorand",
year = "2018",
doi = "10.1002/dmrr.3063",
language = "English",
volume = "34",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
number = "8",

}

Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study. / IMI DIRECT Consortium.

In: Diabetes/Metabolism Research and Reviews, Vol. 34, No. 8, e3063, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

AU - IMI DIRECT Consortium

AU - de las Heras Gala, Tonia

AU - Herder, Christian

AU - Rutters, Femke

AU - Carstensen-Kirberg, Maren

AU - Huth, Cornelia

AU - Stehouwer, Coen D. A.

AU - Nijpels, Giel

AU - Schalkwijk, Casper

AU - Flyvbjerg, Allan

AU - Franks, Paul W.

AU - Dekker, Jacqueline

AU - Meisinger, Christa

AU - Koenig, Wolfgang

AU - Roden, Michael

AU - Rathmann, Wolfgang

AU - Peters, Annette

AU - Thorand, Barbara

PY - 2018

Y1 - 2018

N2 - Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.

AB - Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.

KW - Glycemic deterioration

KW - HbA1c

KW - Inflammation

KW - Insulin resistance

KW - ß-cell function

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054309122&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30114727

U2 - 10.1002/dmrr.3063

DO - 10.1002/dmrr.3063

M3 - Article

VL - 34

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

IS - 8

M1 - e3063

ER -