Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection

Maureen P Martin, Michael M Lederman, Holli B Hutcheson, James J Goedert, George W Nelson, Yvette van Kooyk, Roger Detels, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J O'Brien, Mary Carrington

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Abstract

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.

Original languageEnglish
Pages (from-to)14053-6
Number of pages4
JournalJournal of Virology
Volume78
Issue number24
DOIs
Publication statusPublished - Dec 2004

Cite this

Martin, Maureen P ; Lederman, Michael M ; Hutcheson, Holli B ; Goedert, James J ; Nelson, George W ; van Kooyk, Yvette ; Detels, Roger ; Buchbinder, Susan ; Hoots, Keith ; Vlahov, David ; O'Brien, Stephen J ; Carrington, Mary. / Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. In: Journal of Virology. 2004 ; Vol. 78, No. 24. pp. 14053-6.
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abstract = "There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.",
keywords = "Cell Adhesion Molecules/genetics, Cohort Studies, HIV Infections/genetics, HIV-1/pathogenicity, Humans, Infusions, Parenteral, Lectins, C-Type/genetics, Mucous Membrane, Polymorphism, Genetic, Promoter Regions, Genetic/genetics, Receptors, Cell Surface/genetics",
author = "Martin, {Maureen P} and Lederman, {Michael M} and Hutcheson, {Holli B} and Goedert, {James J} and Nelson, {George W} and {van Kooyk}, Yvette and Roger Detels and Susan Buchbinder and Keith Hoots and David Vlahov and O'Brien, {Stephen J} and Mary Carrington",
year = "2004",
month = "12",
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language = "English",
volume = "78",
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Martin, MP, Lederman, MM, Hutcheson, HB, Goedert, JJ, Nelson, GW, van Kooyk, Y, Detels, R, Buchbinder, S, Hoots, K, Vlahov, D, O'Brien, SJ & Carrington, M 2004, 'Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection' Journal of Virology, vol. 78, no. 24, pp. 14053-6. https://doi.org/10.1128/JVI.78.24.14053-14056.2004

Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. / Martin, Maureen P; Lederman, Michael M; Hutcheson, Holli B; Goedert, James J; Nelson, George W; van Kooyk, Yvette; Detels, Roger; Buchbinder, Susan; Hoots, Keith; Vlahov, David; O'Brien, Stephen J; Carrington, Mary.

In: Journal of Virology, Vol. 78, No. 24, 12.2004, p. 14053-6.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection

AU - Martin, Maureen P

AU - Lederman, Michael M

AU - Hutcheson, Holli B

AU - Goedert, James J

AU - Nelson, George W

AU - van Kooyk, Yvette

AU - Detels, Roger

AU - Buchbinder, Susan

AU - Hoots, Keith

AU - Vlahov, David

AU - O'Brien, Stephen J

AU - Carrington, Mary

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N2 - There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.

AB - There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.

KW - Cell Adhesion Molecules/genetics

KW - Cohort Studies

KW - HIV Infections/genetics

KW - HIV-1/pathogenicity

KW - Humans

KW - Infusions, Parenteral

KW - Lectins, C-Type/genetics

KW - Mucous Membrane

KW - Polymorphism, Genetic

KW - Promoter Regions, Genetic/genetics

KW - Receptors, Cell Surface/genetics

U2 - 10.1128/JVI.78.24.14053-14056.2004

DO - 10.1128/JVI.78.24.14053-14056.2004

M3 - Article

VL - 78

SP - 14053

EP - 14056

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 24

ER -