Association of intercellular adhesion molecule-1 gene with type 1 diabetes

Sergey Nejentsev, Cristian Guja, Rose McCormack, Jason Cooper, Joanna M M Howson, Sarah Nutland, Helen Rance, Neil Walker, Dag Undlien, Kjersti S Ronningen, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Constantin Ionescu-Tirgoviste, Edwin A M Gale, Polly J Bingley, Kathleen M Gillespie, David A Savage, Dennis J Carson, Chris C Patterson, A Peter MaxwellJohn A Todd

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.

Original languageEnglish
Pages (from-to)1723-4
Number of pages2
JournalLancet
Volume362
Issue number9397
DOIs
Publication statusPublished - 22 Nov 2003

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