Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis

Katie Palmer, Emanuele R. Villani, Davide L. Vetrano, Antonio Cherubini, Alfonso J. Cruz-Jentoft, Denis Curtin, Michael Denkinger, Marta Gutiérrez-Valencia, Adalsteinn Guðmundsson, Wilma Knol, Diane V. Mak, Denis O’Mahony, Farhad Pazan, Mirko Petrovic, Chakravarthi Rajkumar, Eva Topinkova, Catarina Trevisan, Tischa J. M. van der Cammen, Rob J. van Marum, Martin WehlingGijsbertus Ziere, Roberto Bernabei, Graziano Onder, On behalf of the European Geriatric Medicine Society Pharmacology special interest group

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To investigate: (1) the cross-sectional association between polypharmacy, hyperpolypharmacy and presence of prefrailty or frailty; (2) the risk of incident prefrailty or frailty in persons with polypharmacy, and vice versa. Methods: A systematic review and meta-analysis was performed according to PRISMA guidelines. We searched PubMed, Web of Science, and Embase from 01/01/1998 to 5/2/2018. Pooled estimates were obtained through random effect models and Mantel–Haenszel weighting. Homogeneity was assessed with the I 2 statistic and publication bias with Egger’s and Begg’s tests. Results: Thirty-seven studies were included. The pooled proportion of polypharmacy in persons with prefrailty and frailty was 47% (95% CI 33–61) and 59% (95% CI 42–76), respectively. Increased odds ratio of polypharmacy were seen for prefrail (pooled OR = 1.52; 95% CI 1.32–1.79) and frail persons (pooled OR = 2.62, 95% CI 1.81–3.79). Hyperpolypharmacy was also increased in prefrail (OR = 1.95; 95% CI 1.41–2.70) and frail (OR = 6.57; 95% CI 9.57–10.48) persons compared to robust persons. Only seven longitudinal studies reported data on the risk of either incident prefrailty or frailty in persons with baseline polypharmacy. A significant higher odds of developing prefrailty was found in robust persons with polypharmacy (pooled OR = 1.30; 95% CI 1.12–1.51). We found no papers investigating polypharmacy incidence in persons with prefrailty/frailty. Conclusions: Polypharmacy is common in prefrail and frail persons, and these individuals are also more likely to be on extreme drug regimens, i.e. hyperpolypharmacy, than robust older persons. More research is needed to investigate the causal relationship between polypharmacy and frailty syndromes, thereby identifying ways to jointly reduce drug burden and prefrailty/frailty in these individuals. Prospero registration number: CRD42018104756.
Original languageEnglish
Pages (from-to)9-36
JournalEuropean Geriatric Medicine
Volume10
Issue number1
DOIs
Publication statusPublished - 15 Feb 2019

Cite this

Palmer, K., Villani, E. R., Vetrano, D. L., Cherubini, A., Cruz-Jentoft, A. J., Curtin, D., ... On behalf of the European Geriatric Medicine Society Pharmacology special interest group (2019). Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis. European Geriatric Medicine, 10(1), 9-36. https://doi.org/10.1007/s41999-018-0124-5