Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women

Anouk E. de Wit, Erik J. Giltay, Marrit K. de Boer, Fokko J. Bosker, Roos C. van der Mast, Hannie C. Comijs, Richard C. Oude Voshaar, Robert A. Schoevers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: Older age and major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and metabolic syndrome (MetS) in men, although associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women. Methods: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons were included. Total testosterone (TT) and sex-hormone binding globulin levels were measured using a second-generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: A higher risk for MetS was found in men with low FT and TT (odds ratio [OR]: 0.67, 95% confidence interval [95%CI]: 0.47-0.95 and OR: 0.51, 95%CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95%CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose, and plasma lipid MetS components at baseline, but not with changes in these components at 2-year follow-up. The associations did not significantly differ between MDD patients and controls. Conclusions: Independently of having MDD, low testosterone levels in men and, in contrast, high testosterone levels in women were significantly associated with MetS and its components.
LanguageEnglish
JournalInternational Journal of Geriatric Psychiatry
DOIs
StateE-pub ahead of print - 2019

Cite this

de Wit, A. E., Giltay, E. J., de Boer, M. K., Bosker, F. J., van der Mast, R. C., Comijs, H. C., ... Schoevers, R. A. (2019). Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. International Journal of Geriatric Psychiatry. DOI: 10.1002/gps.5040
de Wit, Anouk E. ; Giltay, Erik J. ; de Boer, Marrit K. ; Bosker, Fokko J. ; van der Mast, Roos C. ; Comijs, Hannie C. ; Oude Voshaar, Richard C. ; Schoevers, Robert A./ Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. In: International Journal of Geriatric Psychiatry. 2019
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title = "Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women",
abstract = "Objectives: Older age and major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and metabolic syndrome (MetS) in men, although associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women. Methods: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons were included. Total testosterone (TT) and sex-hormone binding globulin levels were measured using a second-generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: A higher risk for MetS was found in men with low FT and TT (odds ratio [OR]: 0.67, 95{\%} confidence interval [95{\%}CI]: 0.47-0.95 and OR: 0.51, 95{\%}CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95{\%}CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose, and plasma lipid MetS components at baseline, but not with changes in these components at 2-year follow-up. The associations did not significantly differ between MDD patients and controls. Conclusions: Independently of having MDD, low testosterone levels in men and, in contrast, high testosterone levels in women were significantly associated with MetS and its components.",
author = "{de Wit}, {Anouk E.} and Giltay, {Erik J.} and {de Boer}, {Marrit K.} and Bosker, {Fokko J.} and {van der Mast}, {Roos C.} and Comijs, {Hannie C.} and {Oude Voshaar}, {Richard C.} and Schoevers, {Robert A.}",
year = "2019",
doi = "10.1002/gps.5040",
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journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
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Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. / de Wit, Anouk E.; Giltay, Erik J.; de Boer, Marrit K.; Bosker, Fokko J.; van der Mast, Roos C.; Comijs, Hannie C.; Oude Voshaar, Richard C.; Schoevers, Robert A.

In: International Journal of Geriatric Psychiatry, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women

AU - de Wit,Anouk E.

AU - Giltay,Erik J.

AU - de Boer,Marrit K.

AU - Bosker,Fokko J.

AU - van der Mast,Roos C.

AU - Comijs,Hannie C.

AU - Oude Voshaar,Richard C.

AU - Schoevers,Robert A.

PY - 2019

Y1 - 2019

N2 - Objectives: Older age and major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and metabolic syndrome (MetS) in men, although associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women. Methods: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons were included. Total testosterone (TT) and sex-hormone binding globulin levels were measured using a second-generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: A higher risk for MetS was found in men with low FT and TT (odds ratio [OR]: 0.67, 95% confidence interval [95%CI]: 0.47-0.95 and OR: 0.51, 95%CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95%CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose, and plasma lipid MetS components at baseline, but not with changes in these components at 2-year follow-up. The associations did not significantly differ between MDD patients and controls. Conclusions: Independently of having MDD, low testosterone levels in men and, in contrast, high testosterone levels in women were significantly associated with MetS and its components.

AB - Objectives: Older age and major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and metabolic syndrome (MetS) in men, although associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women. Methods: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons were included. Total testosterone (TT) and sex-hormone binding globulin levels were measured using a second-generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: A higher risk for MetS was found in men with low FT and TT (odds ratio [OR]: 0.67, 95% confidence interval [95%CI]: 0.47-0.95 and OR: 0.51, 95%CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95%CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose, and plasma lipid MetS components at baseline, but not with changes in these components at 2-year follow-up. The associations did not significantly differ between MDD patients and controls. Conclusions: Independently of having MDD, low testosterone levels in men and, in contrast, high testosterone levels in women were significantly associated with MetS and its components.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30474223

U2 - 10.1002/gps.5040

DO - 10.1002/gps.5040

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JO - International Journal of Geriatric Psychiatry

T2 - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

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