Abstract

The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.

Original languageEnglish
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
DOIs
Publication statusE-pub ahead of print - 14 Aug 2019

Cite this

@article{83842a88753049928fe9f6608e6865d6,
title = "Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years",
abstract = "The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.",
author = "Nienke Legdeur and Tijms, {Betty M} and Elles Konijnenberg and {den Braber}, Anouk and {Ten Kate}, Mara and Sudre, {Carole H} and Jori Tomassen and Maryam Badissi and Maqsood Yaqub and Frederik Barkhof and {van Berckel}, {Bart N} and Boomsma, {Dorret I} and Philip Scheltens and Henne Holstege and Maier, {Andrea B} and Visser, {Pieter Jelle}",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2019",
month = "8",
day = "14",
doi = "10.1093/gerona/glz180",
language = "English",
journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years

AU - Legdeur, Nienke

AU - Tijms, Betty M

AU - Konijnenberg, Elles

AU - den Braber, Anouk

AU - Ten Kate, Mara

AU - Sudre, Carole H

AU - Tomassen, Jori

AU - Badissi, Maryam

AU - Yaqub, Maqsood

AU - Barkhof, Frederik

AU - van Berckel, Bart N

AU - Boomsma, Dorret I

AU - Scheltens, Philip

AU - Holstege, Henne

AU - Maier, Andrea B

AU - Visser, Pieter Jelle

N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/8/14

Y1 - 2019/8/14

N2 - The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.

AB - The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.

U2 - 10.1093/gerona/glz180

DO - 10.1093/gerona/glz180

M3 - Article

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

ER -