Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations

Rachida Rafiq, Floor Walschot, Paul Lips, Hildo J. Lamb, Albert de Roos, Frits R. Rosendaal, Martin den Heijer, Renate T. de Jongh, Renée de Mutsert

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background & aims: Obesity is a well-established risk factor of vitamin D deficiency. However, it is unclear which fat deposit is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations. Our aim was to distinguish the specific contributions of total body fat (TBF), abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations. Methods: We performed a cross-sectional analysis of the Netherlands Epidemiology of Obesity study, a population-based cohort study. We used linear regression analyses to examine associations of TBF, aSAT, VAT (n = 2441) and hepatic fat (n = 1980) with 25(OH)D concentrations. Standardized values were used to compare the different fat deposits. Results: Mean (SD) age and 25(OH)D concentrations of the study population was 56 (6) years and 70.8 (24.2) nmol/L, respectively. TBF was inversely associated with 25(OH)D concentrations in women, but not in men. One percent higher TBF was associated with 0.40 nmol/L (95%CI: −0.67 to −0.13) lower 25(OH)D. aSAT was not associated with 25(OH)D concentrations. One cm2 higher VAT was associated with 0.05 nmol/L (−0.09 to −0.02) lower 25(OH)D in men, and 0.06 nmol/L (−0.10 to −0.01) lower 25(OH)D in women. Hepatic fat was only associated with 25(OH)D in men. A tenfold increase in hepatic fat was associated with 6.21 nmol/L (−10.70 to −1.73) lower 25(OH)D. Regressions with standardized values showed VAT was most strongly related to 25(OH)D. Conclusions: In women, TBF and VAT were inversely related to 25(OH)D concentrations. In men, VAT and hepatic fat were inversely related to 25(OH)D concentrations. In both groups, VAT was most strongly associated with 25(OH)D concentrations.
LanguageEnglish
JournalClinical Nutrition
DOIs
StateE-pub ahead of print - 2019

Cite this

@article{15161808de684d4589bbbcc88e59983f,
title = "Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations",
abstract = "Background & aims: Obesity is a well-established risk factor of vitamin D deficiency. However, it is unclear which fat deposit is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations. Our aim was to distinguish the specific contributions of total body fat (TBF), abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations. Methods: We performed a cross-sectional analysis of the Netherlands Epidemiology of Obesity study, a population-based cohort study. We used linear regression analyses to examine associations of TBF, aSAT, VAT (n = 2441) and hepatic fat (n = 1980) with 25(OH)D concentrations. Standardized values were used to compare the different fat deposits. Results: Mean (SD) age and 25(OH)D concentrations of the study population was 56 (6) years and 70.8 (24.2) nmol/L, respectively. TBF was inversely associated with 25(OH)D concentrations in women, but not in men. One percent higher TBF was associated with 0.40 nmol/L (95{\%}CI: −0.67 to −0.13) lower 25(OH)D. aSAT was not associated with 25(OH)D concentrations. One cm2 higher VAT was associated with 0.05 nmol/L (−0.09 to −0.02) lower 25(OH)D in men, and 0.06 nmol/L (−0.10 to −0.01) lower 25(OH)D in women. Hepatic fat was only associated with 25(OH)D in men. A tenfold increase in hepatic fat was associated with 6.21 nmol/L (−10.70 to −1.73) lower 25(OH)D. Regressions with standardized values showed VAT was most strongly related to 25(OH)D. Conclusions: In women, TBF and VAT were inversely related to 25(OH)D concentrations. In men, VAT and hepatic fat were inversely related to 25(OH)D concentrations. In both groups, VAT was most strongly associated with 25(OH)D concentrations.",
author = "Rachida Rafiq and Floor Walschot and Paul Lips and Lamb, {Hildo J.} and {de Roos}, Albert and Rosendaal, {Frits R.} and Heijer, {Martin den} and {de Jongh}, {Renate T.} and {de Mutsert}, Ren{\'e}e",
year = "2019",
doi = "10.1016/j.clnu.2018.12.018",
language = "English",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",

}

Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations. / Rafiq, Rachida; Walschot, Floor; Lips, Paul; Lamb, Hildo J.; de Roos, Albert; Rosendaal, Frits R.; Heijer, Martin den; de Jongh, Renate T.; de Mutsert, Renée.

In: Clinical Nutrition, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations

AU - Rafiq,Rachida

AU - Walschot,Floor

AU - Lips,Paul

AU - Lamb,Hildo J.

AU - de Roos,Albert

AU - Rosendaal,Frits R.

AU - Heijer,Martin den

AU - de Jongh,Renate T.

AU - de Mutsert,Renée

PY - 2019

Y1 - 2019

N2 - Background & aims: Obesity is a well-established risk factor of vitamin D deficiency. However, it is unclear which fat deposit is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations. Our aim was to distinguish the specific contributions of total body fat (TBF), abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations. Methods: We performed a cross-sectional analysis of the Netherlands Epidemiology of Obesity study, a population-based cohort study. We used linear regression analyses to examine associations of TBF, aSAT, VAT (n = 2441) and hepatic fat (n = 1980) with 25(OH)D concentrations. Standardized values were used to compare the different fat deposits. Results: Mean (SD) age and 25(OH)D concentrations of the study population was 56 (6) years and 70.8 (24.2) nmol/L, respectively. TBF was inversely associated with 25(OH)D concentrations in women, but not in men. One percent higher TBF was associated with 0.40 nmol/L (95%CI: −0.67 to −0.13) lower 25(OH)D. aSAT was not associated with 25(OH)D concentrations. One cm2 higher VAT was associated with 0.05 nmol/L (−0.09 to −0.02) lower 25(OH)D in men, and 0.06 nmol/L (−0.10 to −0.01) lower 25(OH)D in women. Hepatic fat was only associated with 25(OH)D in men. A tenfold increase in hepatic fat was associated with 6.21 nmol/L (−10.70 to −1.73) lower 25(OH)D. Regressions with standardized values showed VAT was most strongly related to 25(OH)D. Conclusions: In women, TBF and VAT were inversely related to 25(OH)D concentrations. In men, VAT and hepatic fat were inversely related to 25(OH)D concentrations. In both groups, VAT was most strongly associated with 25(OH)D concentrations.

AB - Background & aims: Obesity is a well-established risk factor of vitamin D deficiency. However, it is unclear which fat deposit is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations. Our aim was to distinguish the specific contributions of total body fat (TBF), abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations. Methods: We performed a cross-sectional analysis of the Netherlands Epidemiology of Obesity study, a population-based cohort study. We used linear regression analyses to examine associations of TBF, aSAT, VAT (n = 2441) and hepatic fat (n = 1980) with 25(OH)D concentrations. Standardized values were used to compare the different fat deposits. Results: Mean (SD) age and 25(OH)D concentrations of the study population was 56 (6) years and 70.8 (24.2) nmol/L, respectively. TBF was inversely associated with 25(OH)D concentrations in women, but not in men. One percent higher TBF was associated with 0.40 nmol/L (95%CI: −0.67 to −0.13) lower 25(OH)D. aSAT was not associated with 25(OH)D concentrations. One cm2 higher VAT was associated with 0.05 nmol/L (−0.09 to −0.02) lower 25(OH)D in men, and 0.06 nmol/L (−0.10 to −0.01) lower 25(OH)D in women. Hepatic fat was only associated with 25(OH)D in men. A tenfold increase in hepatic fat was associated with 6.21 nmol/L (−10.70 to −1.73) lower 25(OH)D. Regressions with standardized values showed VAT was most strongly related to 25(OH)D. Conclusions: In women, TBF and VAT were inversely related to 25(OH)D concentrations. In men, VAT and hepatic fat were inversely related to 25(OH)D concentrations. In both groups, VAT was most strongly associated with 25(OH)D concentrations.

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U2 - 10.1016/j.clnu.2018.12.018

DO - 10.1016/j.clnu.2018.12.018

M3 - Article

JO - Clinical Nutrition

T2 - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

ER -