Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore

N Padmapriya; J Y Bernard; S Liang; S L Loy; S Cai; I S Zhe; K Kwek; K M Godfrey; P D Gluckman; S M Saw; Y.-S. Chong; J K Y Chan; F Müller-Riemenschneider; A Sheppard; A Chinnadurai; A E Neo Goh; A Rifkin-Graboi; A Qiu; A Biswas; B W Lee; B F P Broekman; B L Quah; B Shuter; C K Chng; C Ngo; C L Bong; C J Henry; C Y Ing Chee; Y T Daniel Goh; D Fok; F Yap; G S Heong Yeo; H Chen; H P S van Bever; I Magiati; I B Yun Wong; I.Y.-M. Lau; J Kapur; J L Richmond; J D Holbrook; J J Gooley; K H Tan; K Niduvaje; L Singh; L L Su; L M Daniel; L.P.-C. Shek; M V Fortier; M Hanson; M.F.-F. Chong; M Rauff; M C Chua; M Meaney; M T Tint; N Karnani; N Lek; O H Teoh; P C Wong; P Agarwal; R M van Dam; S A Rebello; S C Chong; S.-E. Soh; S B Lim; C.-Y.S. Hsu; V S Rajadurai; W Stunkel; W M Han; W W Pang; Y B Cheung; Y H Chan; Y S Lee

doi:10.1186/s12884-017-1537-8

Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore

N Padmapriya, J Y Bernard, S Liang, S L Loy, S Cai, I S Zhe, K Kwek, K M Godfrey, P D Gluckman, S M Saw, Y.-S. Chong, J K Y Chan, F Müller-Riemenschneider, A Sheppard, A Chinnadurai, A E Neo Goh, A Rifkin-Graboi, A Qiu, A Biswas, B W LeeB F P Broekman, B L Quah, B Shuter, C K Chng, C Ngo, C L Bong, C J Henry, C Y Ing Chee, Y T Daniel Goh, D Fok, F Yap, G S Heong Yeo, H Chen, H P S van Bever, I Magiati, I B Yun Wong, I.Y.-M. Lau, J Kapur, J L Richmond, J D Holbrook, J J Gooley, K H Tan, K Niduvaje, L Singh, L L Su, L M Daniel, L.P.-C. Shek, M V Fortier, M Hanson, M.F.-F. Chong, M Rauff, M C Chua, M Meaney, M T Tint, N Karnani, N Lek, O H Teoh, P C Wong, P Agarwal, R M van Dam, S A Rebello, S C Chong, S.-E. Soh, S B Lim, C.-Y.S. Hsu, V S Rajadurai, W Stunkel, W M Han, W W Pang, Y B Cheung, Y H Chan, Y S Lee

APH - Mental Health

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. Methods As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26–28 weeks’ gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression. Results Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend <0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p = 0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively]. Conclusion Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia. Keywords: Physical activity, Sedentary behavior, Gestational diabetes mellitus, Maternal glucose levels, Pregnancy

Original language	English
Journal	BMC Pregnancy and Childbirth
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12884-017-1537-8
Publication status	Published - 2017

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10.1186/s12884-017-1537-8

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Padmapriya, N., Bernard, J. Y., Liang, S., Loy, S. L., Cai, S., Zhe, I. S., Kwek, K., Godfrey, K. M., Gluckman, P. D., Saw, S. M., Chong, Y-S., Chan, J. K. Y., Müller-Riemenschneider, F., Sheppard, A., Chinnadurai, A., Neo Goh, A. E., Rifkin-Graboi, A., Qiu, A., Biswas, A., ... Lee, Y. S. (2017). Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore. BMC Pregnancy and Childbirth, 17(1). https://doi.org/10.1186/s12884-017-1537-8

@article{f05c4e405e5d493e86c2575a42145013,

title = "Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore",

abstract = "Background Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. Methods As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26–28 weeks{\textquoteright} gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression. Results Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend <0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p = 0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively]. Conclusion Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia. Keywords: Physical activity, Sedentary behavior, Gestational diabetes mellitus, Maternal glucose levels, Pregnancy",

author = "N Padmapriya and Bernard, {J Y} and S Liang and Loy, {S L} and S Cai and Zhe, {I S} and K Kwek and Godfrey, {K M} and Gluckman, {P D} and Saw, {S M} and Y.-S. Chong and Chan, {J K Y} and F M{\"u}ller-Riemenschneider and A Sheppard and A Chinnadurai and {Neo Goh}, {A E} and A Rifkin-Graboi and A Qiu and A Biswas and Lee, {B W} and Broekman, {B F P} and Quah, {B L} and B Shuter and Chng, {C K} and C Ngo and Bong, {C L} and Henry, {C J} and {Ing Chee}, {C Y} and {Daniel Goh}, {Y T} and D Fok and F Yap and {Heong Yeo}, {G S} and H Chen and {van Bever}, {H P S} and I Magiati and {Yun Wong}, {I B} and I.Y.-M. Lau and J Kapur and Richmond, {J L} and Holbrook, {J D} and Gooley, {J J} and Tan, {K H} and K Niduvaje and L Singh and Su, {L L} and Daniel, {L M} and L.P.-C. Shek and Fortier, {M V} and M Hanson and M.F.-F. Chong and M Rauff and Chua, {M C} and M Meaney and Tint, {M T} and N Karnani and N Lek and Teoh, {O H} and Wong, {P C} and P Agarwal and {van Dam}, {R M} and Rebello, {S A} and Chong, {S C} and S.-E. Soh and Lim, {S B} and C.-Y.S. Hsu and Rajadurai, {V S} and W Stunkel and Han, {W M} and Pang, {W W} and Cheung, {Y B} and Chan, {Y H} and Lee, {Y S}",

year = "2017",

doi = "10.1186/s12884-017-1537-8",

language = "English",

volume = "17",

journal = "BMC Pregnancy and Childbirth",

issn = "1471-2393",

publisher = "BioMed Central",

number = "1",

}

Padmapriya, N, Bernard, JY, Liang, S, Loy, SL, Cai, S, Zhe, IS, Kwek, K, Godfrey, KM, Gluckman, PD, Saw, SM, Chong, Y-S, Chan, JKY, Müller-Riemenschneider, F, Sheppard, A, Chinnadurai, A, Neo Goh, AE, Rifkin-Graboi, A, Qiu, A, Biswas, A, Lee, BW, Broekman, BFP, Quah, BL, Shuter, B, Chng, CK, Ngo, C, Bong, CL, Henry, CJ, Ing Chee, CY, Daniel Goh, YT, Fok, D, Yap, F, Heong Yeo, GS, Chen, H, van Bever, HPS, Magiati, I, Yun Wong, IB, Lau, IY-M, Kapur, J, Richmond, JL, Holbrook, JD, Gooley, JJ, Tan, KH, Niduvaje, K, Singh, L, Su, LL, Daniel, LM, Shek, LP-C, Fortier, MV, Hanson, M, Chong, MF-F, Rauff, M, Chua, MC, Meaney, M, Tint, MT, Karnani, N, Lek, N, Teoh, OH, Wong, PC, Agarwal, P, van Dam, RM, Rebello, SA, Chong, SC, Soh, S-E, Lim, SB, Hsu, C-YS, Rajadurai, VS, Stunkel, W, Han, WM, Pang, WW, Cheung, YB, Chan, YH & Lee, YS 2017, 'Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore', BMC Pregnancy and Childbirth, vol. 17, no. 1. https://doi.org/10.1186/s12884-017-1537-8

TY - JOUR

T1 - Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore

AU - Padmapriya, N

AU - Bernard, J Y

AU - Liang, S

AU - Loy, S L

AU - Cai, S

AU - Zhe, I S

AU - Kwek, K

AU - Godfrey, K M

AU - Gluckman, P D

AU - Saw, S M

AU - Chong, Y.-S.

AU - Chan, J K Y

AU - Müller-Riemenschneider, F

AU - Sheppard, A

AU - Chinnadurai, A

AU - Neo Goh, A E

AU - Rifkin-Graboi, A

AU - Qiu, A

AU - Biswas, A

AU - Lee, B W

AU - Broekman, B F P

AU - Quah, B L

AU - Shuter, B

AU - Chng, C K

AU - Ngo, C

AU - Bong, C L

AU - Henry, C J

AU - Ing Chee, C Y

AU - Daniel Goh, Y T

AU - Fok, D

AU - Yap, F

AU - Heong Yeo, G S

AU - Chen, H

AU - van Bever, H P S

AU - Magiati, I

AU - Yun Wong, I B

AU - Lau, I.Y.-M.

AU - Kapur, J

AU - Richmond, J L

AU - Holbrook, J D

AU - Gooley, J J

AU - Tan, K H

AU - Niduvaje, K

AU - Singh, L

AU - Su, L L

AU - Daniel, L M

AU - Shek, L.P.-C.

AU - Fortier, M V

AU - Hanson, M

AU - Chong, M.F.-F.

AU - Rauff, M

AU - Chua, M C

AU - Meaney, M

AU - Tint, M T

AU - Karnani, N

AU - Lek, N

AU - Teoh, O H

AU - Wong, P C

AU - Agarwal, P

AU - van Dam, R M

AU - Rebello, S A

AU - Chong, S C

AU - Soh, S.-E.

AU - Lim, S B

AU - Hsu, C.-Y.S.

AU - Rajadurai, V S

AU - Stunkel, W

AU - Han, W M

AU - Pang, W W

AU - Cheung, Y B

AU - Chan, Y H

AU - Lee, Y S

PY - 2017

Y1 - 2017

N2 - Background Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. Methods As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26–28 weeks’ gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression. Results Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend <0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p = 0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively]. Conclusion Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia. Keywords: Physical activity, Sedentary behavior, Gestational diabetes mellitus, Maternal glucose levels, Pregnancy

AB - Background Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. Methods As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26–28 weeks’ gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression. Results Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend <0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p = 0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively]. Conclusion Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia. Keywords: Physical activity, Sedentary behavior, Gestational diabetes mellitus, Maternal glucose levels, Pregnancy

U2 - 10.1186/s12884-017-1537-8

DO - 10.1186/s12884-017-1537-8

M3 - Article

C2 - 29047402

VL - 17

JO - BMC Pregnancy and Childbirth

JF - BMC Pregnancy and Childbirth

SN - 1471-2393

IS - 1

ER -