Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology: a systematic review

Urvi Joshi, Pieter G H M Raijmakers, Ingrid I Riphagen, Gerrit J J Teule, Arthur van Lingen, Otto S Hoekstra

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.

PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).

RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.

CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalMolecular Imaging and Biology
Volume9
Issue number3
DOIs
Publication statusPublished - 24 Feb 2007

Cite this

@article{f89790b3d72a4a2f8ae045709d149041,
title = "Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology: a systematic review",
abstract = "PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97{\%} for AC and 62/99{\%} for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98{\%} [95{\%} confidence interval (95{\%} CI): 96-99{\%}, n = 1,012 lesions] for FR-PET, and 88{\%} (95{\%} CI:81-94{\%}, n = 288 lesions) for DH-PET.CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.",
keywords = "Fluorodeoxyglucose F18, Humans, Neoplasms/diagnostic imaging, Positron-Emission Tomography/methods, Radiopharmaceuticals, Sensitivity and Specificity, FDG PET, Attenuation correction, lesions, Review of the literature",
author = "Urvi Joshi and Raijmakers, {Pieter G H M} and Riphagen, {Ingrid I} and Teule, {Gerrit J J} and {van Lingen}, Arthur and Hoekstra, {Otto S}",
year = "2007",
month = "2",
day = "24",
doi = "10.1007/s11307-007-0076-5",
language = "English",
volume = "9",
pages = "99--105",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "Springer New York",
number = "3",

}

Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology : a systematic review. / Joshi, Urvi; Raijmakers, Pieter G H M; Riphagen, Ingrid I; Teule, Gerrit J J; van Lingen, Arthur; Hoekstra, Otto S.

In: Molecular Imaging and Biology, Vol. 9, No. 3, 24.02.2007, p. 99-105.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology

T2 - a systematic review

AU - Joshi, Urvi

AU - Raijmakers, Pieter G H M

AU - Riphagen, Ingrid I

AU - Teule, Gerrit J J

AU - van Lingen, Arthur

AU - Hoekstra, Otto S

PY - 2007/2/24

Y1 - 2007/2/24

N2 - PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.

AB - PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Neoplasms/diagnostic imaging

KW - Positron-Emission Tomography/methods

KW - Radiopharmaceuticals

KW - Sensitivity and Specificity

KW - FDG PET

KW - Attenuation correction

KW - lesions

KW - Review of the literature

U2 - 10.1007/s11307-007-0076-5

DO - 10.1007/s11307-007-0076-5

M3 - Review article

VL - 9

SP - 99

EP - 105

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

IS - 3

ER -