Abstract
PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.
PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).
RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.
CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.
| Original language | English |
|---|---|
| Pages (from-to) | 99-105 |
| Number of pages | 7 |
| Journal | Molecular Imaging and Biology |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 24 Feb 2007 |
Cite this
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Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology : a systematic review. / Joshi, Urvi; Raijmakers, Pieter G H M; Riphagen, Ingrid I; Teule, Gerrit J J; van Lingen, Arthur; Hoekstra, Otto S.
In: Molecular Imaging and Biology, Vol. 9, No. 3, 24.02.2007, p. 99-105.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology
T2 - a systematic review
AU - Joshi, Urvi
AU - Raijmakers, Pieter G H M
AU - Riphagen, Ingrid I
AU - Teule, Gerrit J J
AU - van Lingen, Arthur
AU - Hoekstra, Otto S
PY - 2007/2/24
Y1 - 2007/2/24
N2 - PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.
AB - PURPOSE: To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.PROCEDURES: Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).RESULTS: Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.CONCLUSIONS: Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Neoplasms/diagnostic imaging
KW - Positron-Emission Tomography/methods
KW - Radiopharmaceuticals
KW - Sensitivity and Specificity
KW - FDG PET
KW - Attenuation correction
KW - lesions
KW - Review of the literature
U2 - 10.1007/s11307-007-0076-5
DO - 10.1007/s11307-007-0076-5
M3 - Review article
VL - 9
SP - 99
EP - 105
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
SN - 1536-1632
IS - 3
ER -