Autoimmunity to neuronal proteins in neurological disorder

Sandra Amor*, Ruth Huizinga

*Corresponding author for this work

Research output: Book/ReportBookAcademicpeer-review

Abstract

The brain is often thought of as an immune-privilege site, implying that trafficking of immune cells and molecules into the central nervous system is limited or controlled so as to prevent collateral damage. Nevertheless, there is increasing evidence demonstrating complex interactions between the immune system and the nervous systems. The increasing evidence for the role of autoimmunity to neuronal proteins in both peripheral and central nervous system disorders has led to the development of animal models and in vitro systems to probe human disorders. This book reviews evidence for autoimmunity to neurons and axons in neurological diseases, discusses the animal models that are used to study the mechanisms of disease and indicates how such autoimmunity is relevant for therapies in these disorders.

Original languageEnglish
PublisherNOVA Science publishers, Inc.
Number of pages142
ISBN (Electronic)9781536113167
ISBN (Print)9781613243978
Publication statusPublished - 2011

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