Autologous cell suspension grafting in segmental vitiligo and piebaldism: a randomized controlled trial comparing full surface and fractional CO2 laser recipient-site preparations

J. E. Lommerts, A. A. Meesters, L. Komen, M. W. Bekkenk, M. A. de Rie, R. M. Luiten, A. Wolkerstorfer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Autologous noncultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though the optimal laser settings and ablation depth are unknown. Objectives: To assess the efficacy and safety of less invasive recipient-site preparations. Methods: In a randomized, observer-blinded, controlled trial we compared different recipient-site preparations before cell suspension transplantation in segmental vitiligo and piebaldism. In each patient, we randomly allocated three CO2 laser recipient-site preparations (209 and 144 μm full surface, and fractional) and a control (no treatment) to four depigmentations. After 6 months we assessed repigmentation and side-effects. Results: We included 10 patients with vitiligo (n = 3) and piebaldism (n = 7). Compared with the control site, we found more repigmentation after full surface ablation at 209 μm (median 68·7%, P = 0·01) and 144 μm (median 58·3%, P = 0·007), but no repigmentation after fractional ablation (median 0·0%, P = 0·14). Conclusions: Superficial full surface ablation with a depth of 144 μm is an effective recipient-site preparation before cell suspension transplantation, while fractional CO2 laser is not.

Original languageEnglish
Pages (from-to)1293-1298
Number of pages6
JournalBritish Journal of Dermatology
Volume177
Issue number5
DOIs
Publication statusPublished - 1 Nov 2017

Cite this

@article{ba524610a01b40aa8403df0b3ee999a7,
title = "Autologous cell suspension grafting in segmental vitiligo and piebaldism: a randomized controlled trial comparing full surface and fractional CO2 laser recipient-site preparations",
abstract = "Background: Autologous noncultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though the optimal laser settings and ablation depth are unknown. Objectives: To assess the efficacy and safety of less invasive recipient-site preparations. Methods: In a randomized, observer-blinded, controlled trial we compared different recipient-site preparations before cell suspension transplantation in segmental vitiligo and piebaldism. In each patient, we randomly allocated three CO2 laser recipient-site preparations (209 and 144 μm full surface, and fractional) and a control (no treatment) to four depigmentations. After 6 months we assessed repigmentation and side-effects. Results: We included 10 patients with vitiligo (n = 3) and piebaldism (n = 7). Compared with the control site, we found more repigmentation after full surface ablation at 209 μm (median 68·7{\%}, P = 0·01) and 144 μm (median 58·3{\%}, P = 0·007), but no repigmentation after fractional ablation (median 0·0{\%}, P = 0·14). Conclusions: Superficial full surface ablation with a depth of 144 μm is an effective recipient-site preparation before cell suspension transplantation, while fractional CO2 laser is not.",
author = "Lommerts, {J. E.} and Meesters, {A. A.} and L. Komen and Bekkenk, {M. W.} and {de Rie}, {M. A.} and Luiten, {R. M.} and A. Wolkerstorfer",
year = "2017",
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language = "English",
volume = "177",
pages = "1293--1298",
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Autologous cell suspension grafting in segmental vitiligo and piebaldism : a randomized controlled trial comparing full surface and fractional CO2 laser recipient-site preparations. / Lommerts, J. E.; Meesters, A. A.; Komen, L.; Bekkenk, M. W.; de Rie, M. A.; Luiten, R. M.; Wolkerstorfer, A.

In: British Journal of Dermatology, Vol. 177, No. 5, 01.11.2017, p. 1293-1298.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Autologous cell suspension grafting in segmental vitiligo and piebaldism

T2 - a randomized controlled trial comparing full surface and fractional CO2 laser recipient-site preparations

AU - Lommerts, J. E.

AU - Meesters, A. A.

AU - Komen, L.

AU - Bekkenk, M. W.

AU - de Rie, M. A.

AU - Luiten, R. M.

AU - Wolkerstorfer, A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: Autologous noncultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though the optimal laser settings and ablation depth are unknown. Objectives: To assess the efficacy and safety of less invasive recipient-site preparations. Methods: In a randomized, observer-blinded, controlled trial we compared different recipient-site preparations before cell suspension transplantation in segmental vitiligo and piebaldism. In each patient, we randomly allocated three CO2 laser recipient-site preparations (209 and 144 μm full surface, and fractional) and a control (no treatment) to four depigmentations. After 6 months we assessed repigmentation and side-effects. Results: We included 10 patients with vitiligo (n = 3) and piebaldism (n = 7). Compared with the control site, we found more repigmentation after full surface ablation at 209 μm (median 68·7%, P = 0·01) and 144 μm (median 58·3%, P = 0·007), but no repigmentation after fractional ablation (median 0·0%, P = 0·14). Conclusions: Superficial full surface ablation with a depth of 144 μm is an effective recipient-site preparation before cell suspension transplantation, while fractional CO2 laser is not.

AB - Background: Autologous noncultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though the optimal laser settings and ablation depth are unknown. Objectives: To assess the efficacy and safety of less invasive recipient-site preparations. Methods: In a randomized, observer-blinded, controlled trial we compared different recipient-site preparations before cell suspension transplantation in segmental vitiligo and piebaldism. In each patient, we randomly allocated three CO2 laser recipient-site preparations (209 and 144 μm full surface, and fractional) and a control (no treatment) to four depigmentations. After 6 months we assessed repigmentation and side-effects. Results: We included 10 patients with vitiligo (n = 3) and piebaldism (n = 7). Compared with the control site, we found more repigmentation after full surface ablation at 209 μm (median 68·7%, P = 0·01) and 144 μm (median 58·3%, P = 0·007), but no repigmentation after fractional ablation (median 0·0%, P = 0·14). Conclusions: Superficial full surface ablation with a depth of 144 μm is an effective recipient-site preparation before cell suspension transplantation, while fractional CO2 laser is not.

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U2 - 10.1111/bjd.15569

DO - 10.1111/bjd.15569

M3 - Article

VL - 177

SP - 1293

EP - 1298

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 5

ER -