Avidity regulation of integrins: the driving force in leukocyte adhesion

Y van Kooyk, C G Figdor

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.

Original languageEnglish
Pages (from-to)542-7
Number of pages6
JournalCurrent opinion in cell biology
Volume12
Issue number5
Publication statusPublished - Oct 2000

Cite this

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title = "Avidity regulation of integrins: the driving force in leukocyte adhesion",
abstract = "The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.",
keywords = "Animals, Binding, Competitive, Cell Adhesion, Cell Adhesion Molecules/metabolism, Cytoskeleton/metabolism, Humans, Leukocytes/cytology, Lymphocyte Function-Associated Antigen-1/metabolism",
author = "{van Kooyk}, Y and Figdor, {C G}",
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journal = "Current opinion in cell biology",
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Avidity regulation of integrins : the driving force in leukocyte adhesion. / van Kooyk, Y; Figdor, C G.

In: Current opinion in cell biology, Vol. 12, No. 5, 10.2000, p. 542-7.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Avidity regulation of integrins

T2 - the driving force in leukocyte adhesion

AU - van Kooyk, Y

AU - Figdor, C G

PY - 2000/10

Y1 - 2000/10

N2 - The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.

AB - The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.

KW - Animals

KW - Binding, Competitive

KW - Cell Adhesion

KW - Cell Adhesion Molecules/metabolism

KW - Cytoskeleton/metabolism

KW - Humans

KW - Leukocytes/cytology

KW - Lymphocyte Function-Associated Antigen-1/metabolism

M3 - Review article

VL - 12

SP - 542

EP - 547

JO - Current opinion in cell biology

JF - Current opinion in cell biology

SN - 0955-0674

IS - 5

ER -