Abstract
The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.
| Original language | English |
|---|---|
| Pages (from-to) | 542-7 |
| Number of pages | 6 |
| Journal | Current opinion in cell biology |
| Volume | 12 |
| Issue number | 5 |
| Publication status | Published - Oct 2000 |
Cite this
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Avidity regulation of integrins : the driving force in leukocyte adhesion. / van Kooyk, Y; Figdor, C G.
In: Current opinion in cell biology, Vol. 12, No. 5, 10.2000, p. 542-7.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Avidity regulation of integrins
T2 - the driving force in leukocyte adhesion
AU - van Kooyk, Y
AU - Figdor, C G
PY - 2000/10
Y1 - 2000/10
N2 - The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.
AB - The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.
KW - Animals
KW - Binding, Competitive
KW - Cell Adhesion
KW - Cell Adhesion Molecules/metabolism
KW - Cytoskeleton/metabolism
KW - Humans
KW - Leukocytes/cytology
KW - Lymphocyte Function-Associated Antigen-1/metabolism
M3 - Review article
VL - 12
SP - 542
EP - 547
JO - Current opinion in cell biology
JF - Current opinion in cell biology
SN - 0955-0674
IS - 5
ER -